Magnetic Resonance Imaging in Evaluating Response to RadiationTherapy in Patients With High Grade Glioma

Detailed DescriptionOBJECTIVES:

I. To develop a multimodality statistical model to act as a surrogate marker scheme of early
changes in high grade glioma patients undergoing radiation therapy, using conventional MRI,
MR diffusion tensor imaging, perfusion, permeability, and spectroscopic imaging while
incorporating the radiation dose calculations delivered locally and the results of a
clinical questionnaire into the model.

II. To assess treatment response to tumor and normal tissue changes. OUTLINE: Patients
undergo multimodality MRI imaging at baseline, weeks 1, 2, 3, 5, and 6, and then 4-6 weeks
after completion of radiation therapy.

Inclusion Criteria:

- Patients being treated for diagnosed with high grade glioma (WHO grade III or IV) at
the University of Pennsylvania Medical Center who will be undergoing radiation
therapy to the brain

- Patient or legal representative able to provide written informed consent

- Adult males and nonpregnant females

Exclusion Criteria:

- Vulnerable populations as specified (including pregnant patients, prisoners, patients
with pacemakers or metallic implants)

- Patients with renal failure

- Patients with any condition considered a contraindication to MRI