Nicotine Lozenge or Tobacco-Free Snuff for Smokeless Tobacco Reduction
| Status: | Archived |
|---|---|
| Conditions: | Smoking Cessation, Tobacco Consumers |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | January 2009 |
| End Date: | September 2010 |
A Pilot Study to Compare the Nicotine Lozenge and Tobacco-Free Snuff for Smokeless Tobacco Reduction
Smokeless tobacco (ST) is a known human carcinogen. Long-term ST use is known to increase
the risk for oropharyngeal cancer. Extant literature on cigarette smokers suggests that
smoking reduction increases smoking abstinence among smokers not interested in quitting.
The overarching goal of this line of research is to develop a ST reduction intervention
among ST users not interested in quitting tobacco. Our first step is to conduct the
proposed pilot study designed to assess the efficacy of the nicotine lozenges or
tobacco-free snuff for reducing ST use or facilitating ST abstinence among ST users not
interested in quitting.
In this study, we will enroll 80 subjects who will be randomized to either the nicotine
lozenge or tobacco-free snuff to reduce their ST use over 8 weeks with follow-up at 12
weeks. Forty subjects will be recruited at Mayo Clinic in Rochester, MN, and 40 subjects
will be recruited at the Oregon Research Institute in Eugene, Oregon.
We found this trial at
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