Delayed Cord Clamping in Premature Infants
| Status: | Completed |
|---|---|
| Conditions: | Hospital, Anemia |
| Therapuetic Areas: | Hematology, Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 2/7/2015 |
| Start Date: | September 2009 |
| End Date: | March 2012 |
| Contact: | Anthony Wartell, MD |
| Email: | anthony.wartell@ucdmc.ucdavis.edu |
| Phone: | 916-703-3050 |
Delayed Cord Clamping: Prevention of Anemia and Hypothermia in Premature Infants
Delayed cord clamping has been shown to decrease the risk of bleeding in the brain of
premature infants. However this procedure is not standard due to concerns that the
premature infant will get too cold. In this study the investigators look at using a plastic
covering and a chemical warmer to keep the small premature baby warm while waiting 30-60
seconds to clamp the umbilical cord.
premature infants. However this procedure is not standard due to concerns that the
premature infant will get too cold. In this study the investigators look at using a plastic
covering and a chemical warmer to keep the small premature baby warm while waiting 30-60
seconds to clamp the umbilical cord.
Enrolled premature infants will be compared to age matched historical controls that did not
receive delayed cord clamping but were placed under a warmer immediately after birth.
Outcomes to be analyzed include initial body temperature, hematocrit at birth and 24 hours
of age, number of red blood cell transfusions during hospital stay, umbilical cord gas,
first blood gas following delivery, blood pressure data in the first 24 hours, fluid bolus
and inotrope requirement in the first 24 hours, incidence of intraventricular hemorrhage and
late-onset sepsis, peak bilirubin level, length of phototherapy, and Apgar scores.
receive delayed cord clamping but were placed under a warmer immediately after birth.
Outcomes to be analyzed include initial body temperature, hematocrit at birth and 24 hours
of age, number of red blood cell transfusions during hospital stay, umbilical cord gas,
first blood gas following delivery, blood pressure data in the first 24 hours, fluid bolus
and inotrope requirement in the first 24 hours, incidence of intraventricular hemorrhage and
late-onset sepsis, peak bilirubin level, length of phototherapy, and Apgar scores.
Inclusion Criteria:
- premature infants at 24-28 completed weeks gestation at the time of delivery
- informed consent obtained from parents prior to delivery
Exclusion Criteria:
- multiple gestation (twins, triplets, etc)
- prolonged fetal bradycardia
- placental abruption or previa
- maternal illness
- major congenital anomalies
- maternal fever in labor
- fetal illness (e.g. isoimmune hemolysis)
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