Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas



Status:Terminated
Conditions:Ocular, Dermatology
Therapuetic Areas:Dermatology / Plastic Surgery, Ophthalmology
Healthy:No
Age Range:8 - Any
Updated:10/13/2018
Start Date:October 1, 2009
End Date:February 3, 2017

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Trial Summary
Trial Overview
Inclusion Criteria
To evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen
(CXL) as a method to increase the biomechanical and biochemical stability of the cornea by
inducing additional cross-links within or between collagen fibers using UVA light and the
photo- mediator riboflavin. The purpose of this study is to generate data for presentation at
medical meetings and for peer-review publication


Inclusion Criteria:

- 8 years of age or older

- Diagnosis of keratoconus, post-LASIK ectasia, or pellucid marginal degeneration or
forme fruste pellucid marginal degeneration.

- Diagnosis of FFKC

- History of Radial Keratotomy with fluctuating vision.

- Terrien's Marginal Degeneration

- Ability to provide written informed consent

- Likely to complete all study visits

- Minimum corneal thickness of at least 300 250 microns measured by ultrasound or
Pentacam for all indications other than Terriens. For Terriens, the minimal corneal
thickness should be consistent with the surgeon's best surgical judgment.

Exclusion Criteria:

- Severe corneal scarring that markedly affects vision

- Contraindications to any study medications or their components

- Pregnancy or breast feeding

- Active Herpes Corneal Disease
We found this trial at
3
sites
TLC Laser Eye Center
Fairfax, Virginia 22031
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Fairfax, VA
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Center for Excellence in Eye Care
Miami, Florida 33176
Phone: 305-598-2020
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Miami, FL
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TLC Laser Eye Center
Rockville, Maryland 20852
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Rockville, MD
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