Fabry Disease Registry

The Fabry Registry is an ongoing, international multi-center, strictly observational program
that tracks the routine clinical outcomes for patients with Fabry disease, irrespective of
treatment status. No experimental intervention is involved; patients in the Registry undergo
clinical assessments and receive care as determined by the patient's treating physician.

The objectives of the Registry are:

- To enhance the understanding of the variability, progression, and natural history of
Fabry disease, including heterozygous females with the disease;

- To assist the Fabry medical community with the development of recommendations for
monitoring patients and reports on patient outcomes to help optimize patient care;

- To characterize and describe the Fabry population as a whole; and

- To evaluate the long-term safety and effectiveness of Fabrazyme®