MRI-Guided Radiation Therapy in Treating Patients Who Have Undergone Surgery to Remove the Prostate
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Prostate Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | June 2009 |
A Prospective Study Implementing MRI Based Treatment Planning for Clinical Target Volume Definition and Immobilization in Post-Prostatectomy Radiation Treatment
This is a prospective clinical trial examining the use of MRI to measure internal organ
motion and any resulting changes in the target volume (shape and location) during a course
of post-operative radiation therapy for prostate cancer. The goal is to better understand
and characterize these physiologic variations so that they can be accounted for during the
treatment planning process. The ultimate longer-term clinical goal here is to provide a form
of adaptive radiation therapy in the future, such that if major changes are seen over an
8-week course of radiation therapy in our study. This may argue for hypofractionating those
patients who are most likely to have major shifts over time.
motion and any resulting changes in the target volume (shape and location) during a course
of post-operative radiation therapy for prostate cancer. The goal is to better understand
and characterize these physiologic variations so that they can be accounted for during the
treatment planning process. The ultimate longer-term clinical goal here is to provide a form
of adaptive radiation therapy in the future, such that if major changes are seen over an
8-week course of radiation therapy in our study. This may argue for hypofractionating those
patients who are most likely to have major shifts over time.
PRIMARY OBJECTIVES:
I. To evaluate the use of MRI in delineating clinical target volumes, as well as endorectal
balloon target immobilization in patients treated with radiation following radical
prostatectomy.
SECONDARY OBJECTIVES:
II. Trends over time in CTV, bladder and rectum volumes and percent change from baseline at
each time point. III. Frequency of events in which the CTV falls outside the PTV. IV.
Proportion of the total CTV which falls outside the PTV at each event. V. Trends over time
in dose-volume exposures for bladder and rectum.
OUTLINE: Patients undergo MRI and CT scan-based simulation for treatment planning with
endorectal balloon target immobilization. The treatment target volumes and surrounding
organs at risk are contoured, treatment plan developed and approved.
Patients then undergo 39 fractions of image-guided intensity-modulated radiotherapy over 8
weeks. Patients also undergo weekly MRI scans of the pelvis (in the planned treatment
position) during radiotherapy.
I. To evaluate the use of MRI in delineating clinical target volumes, as well as endorectal
balloon target immobilization in patients treated with radiation following radical
prostatectomy.
SECONDARY OBJECTIVES:
II. Trends over time in CTV, bladder and rectum volumes and percent change from baseline at
each time point. III. Frequency of events in which the CTV falls outside the PTV. IV.
Proportion of the total CTV which falls outside the PTV at each event. V. Trends over time
in dose-volume exposures for bladder and rectum.
OUTLINE: Patients undergo MRI and CT scan-based simulation for treatment planning with
endorectal balloon target immobilization. The treatment target volumes and surrounding
organs at risk are contoured, treatment plan developed and approved.
Patients then undergo 39 fractions of image-guided intensity-modulated radiotherapy over 8
weeks. Patients also undergo weekly MRI scans of the pelvis (in the planned treatment
position) during radiotherapy.
Inclusion
- Completion of a radical prostatectomy for adenocarcinoma of the prostate
- Scheduled post-operative radiation therapy as part of the patient's treatment for
prostate cancer
- Subjects are capable of giving informed consent
Exclusion
- The presence of grossly visualized or palpable disease recurrence
- Patients who are unable to undergo an MRI scan such as those with an implanted
permanent pacemaker or ICD
- Patients with metastatic disease or an increasing PSA
We found this trial at
1
site
3400 Civic Center Blvd
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
(215) 662-6065
Abramson Cancer Center of the University of Pennsylvania The Abramson Cancer Center of the University...
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