Classification of Heart Failure With Preserved Ejection Fraction

Patients with HFpEF are a heterogeneous group with varying etiology and pathophysiology,
which may play a large role in the difficulty in managing these patients and enrolling them
in clinical trials. A major advance in the care of patients with HFpEF would be a
classification system based on etiology, pathophysiology, and/or genetic factors as well as
machine learning analyses. The ultimate goal of this study is to demonstrate that it is
possible to better classify patients with HFpEF based on etiologic, pathophysiologic, and
genetic differences between patients. If successful, this study could lead to: (1) novel risk
estimation in patients with HFpEF and (2) more fruitful clinical trials based on targeting
specific subsets of HFpEF.

Inclusion Criteria:

- Age > 21 years

- Signs or symptoms of congestive heart failure

- Left ventricular ejection fraction > 50%

Exclusion Criteria:

- Severe valvular heart disease

- History of cardiac transplantation

- Prior history of heart failure associated with left ventricular ejection fraction <
35%