A Study of the HSP90 Inhibitor, STA-9090 in Subjects With Stage IIIB or IV Non-Small Cell Lung Cancer (NSCLC)



Status:Completed
Conditions:Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/1/2014
Start Date:November 2009
End Date:June 2013
Contact:Kelly Maslin
Email:kmaslin@syntapharma.com
Phone:781-541-7150

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Trial Summary
Trial Overview
Inclusion Criteria

A Non-Randomized, Open-label, Multi-Center, Multi-Cohort Phase 2 Study Evaluating the Efficacy and Safety of STA-9090 in Subjects With Stage IIIB or IV Non-Small Cell Lung Cancer

This is a phase 2 study of the HSP90 inhibitor, STA-9090 (ganetespib) in subjects with stage
IIIB or IV non-small cell lung cancer (NSCLC).


Inclusion Criteria:

- Pathologically confirmed diagnosis of Stage IIIB (with pleural effusion) or Stage IV
NSCLC with measurable disease by RECIST and evidence of progression

- Availability of tissue for analysis

- ECOG Performance Status 0 or 1

- Adequate organ function as defined in the protocol.

- Must be at least 18 years old and able and willing to sign a written informed consent
document

Exclusion Criteria:

- Poor venous access requiring an indwelling catheter for study drug administration

- Women who are pregnant or lactating

- Ventricular ejection fraction < or = to 55% at baseline

- Any uncontrolled intercurrent illness
We found this trial at
21
sites
Massachusetts General Hospital
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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Boston, MA
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Beth Israel Deaconess Medical Center
330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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Boston, MA
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Vanderbilt-Ingram Cancer Center
2220 Pierce Ave
Nashville, Tennessee 37232
615-936-8422
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
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Nashville, TN
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Oregon Health and Science University
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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Portland, OR
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Winship Cancer Institute at Emory University
1365 Clifton Rd NE
Atlanta, Georgia 30322
(404) 778-1900
Winship Cancer Institute at Emory University Winship Cancer Institute of Emory University is Georgia
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Atlanta, GA
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University of Colorado Cancer Center - Anschutz Cancer Pavilion
13001 E. 17th Pl.
Aurora, Colorado 80045
303-724-5000
University of Colorado Cancer Center - Anschutz Cancer Pavilion The University of Colorado Denver |...
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Aurora, CO
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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland 21231
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Baltimore, MD
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Dana-Farber Cancer Institute
450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston, MA
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University of North Carolina Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
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Chapel Hill, NC
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Rush University Medical Center
1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
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Chicago, IL
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University of Chicago Medical Center
5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
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Chicago, IL
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U.T. Southwestern Medical Center
2201 Inwood Rd
Dallas, Texas 75235
(214) 645-8300
U.T. Southwestern Medical Center The story of UT Southwestern Medical Center is one of commitment...
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Dallas, TX
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City of Hope National Medical Center
1500 East Duarte Road
Duarte, California 91010
626-256-HOPE (4673)
City of Hope National Medical Center City of Hope is dedicated to making a difference...
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Duarte, CA
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Hackensack University Medical Center
30 Prospect Ave
Hackensack, New Jersey 07601
(201) 996-2000
Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
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Hackensack, NJ
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Penn State Hershey Cancer Institute
Hershey, Pennsylvania 17033
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Hershey, PA
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Genesis Cancer Center
Hot Springs, Arkansas 71913
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Hot Springs, AR
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Nevada Cancer Institute
Las Vegas, Nevada 89135
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Las Vegas, NV
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UCLA Health System
Santa Monica, California 90404
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Santa Monica, CA
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Swedish Medical Center
5300 Tallman Ave NW
Seattle, Washington 98122
(206) 782-2700
Swedish Medical Center Since 1910, Swedish has been the region's hallmark for excellence in health...
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Seattle, WA
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Arizona Cancer Center, University of Arizona
Tucson, Arizona 85724
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Tucson, AZ
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Piedmont Hematology Oncology Associates PA
Winston Salem, North Carolina 27103
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Winston Salem, NC
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