An Open Label Trial for Treating Carpometacarpal Osteoarthritis of the Thumb: Pilot Study
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Osteoarthritis (OA) |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 45 - 95 |
| Updated: | 5/27/2013 |
| Start Date: | October 2004 |
| End Date: | December 2009 |
| Contact: | Nadia Baranchuk |
| Email: | baranchukn@hss.edu |
| Phone: | 212-774-2960 |
An Open Label Trial for Treating Carpometacarpal Osteoarthritis: A Pilot Study Sub Study: Validation of the Strength-Dexterity Test in Subjects Without Carpometacarpal Osteoarthritis
The purpose of this study is to find out if hyaluronan, an injectable medication for knee
arthritis, also works for arthritis at the base of the thumb. This study will also evaluate
how good ultrasound is at visualizing medication in the thumb joint. We are no longer
recruiting for this part of the open label trial.
In a sub-study including 20 age-matched subjects without arthritis to validate the manual
Strength-Dexterity Test. We are currently recruiting subjects without arthritis for our
control sub-study.
Inclusion Criteria:
- Radiographic evidence of at least moderate narrowing (joint space < 1mm) or the
presence of osteophytes or sclerosis at the CMC joint
- Patient complaint of unacceptable pain despite modification of activity, a trial of
splinting and a therapeutic dose of NSAIDS
- If bilateral disease, only the most severely involved hand, (as defined by VAS for
pain), will be entered in the study.
- Proficiency in English.
Exclusion Criteria:
- Previous bad injury to the thumb
- Previous hand surgery on the study thumb
- Known hand comorbidities (i.e. carpal tunnel syndrome, de Quervains Tenosynovitis
etc)
- Rheumatoid arthritis or lupus
- Bleeding problems
- Being on blood thinners (except aspirin)
- Known allergies to any of the medications being used
- Allergies to chicken products
- Current use of oral steroids
- Cancer that is not cured or in remission
- Severe diabetes
- A serious infection somewhere else in the subject's body
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Hospital for Special Surgery Founded in 1863, Hospital for Special Surgery is the nation
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