Proton Beam Radiation Therapy in Treating Patients With Retroperitoneal Sarcoma
| Status: | Archived |
|---|---|
| Conditions: | Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | November 2009 |
| End Date: | November 2014 |
Proton Radiotherapy for Retroperitoneal Sarcoma
RATIONALE: Specialized radiation therapy, such as proton beam radiation therapy, that
delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause
less damage to normal tissue in patients with retroperitoneal sarcoma. PURPOSE: This phase I
trial is studying the side effects and and best dose of proton beam radiation therapy in
treating patients with retroperitoneal sarcoma.
Detailed DescriptionPRIMARY OBJECTIVES:
I. To determine the feasibility and toxicity of proton radiotherapy for retroperitoneal
sarcomas.
II. To determine the maximum safe proton radiotherapy dose for retroperitoneal sarcomas.
III. To determine the maximally tolerated dose of proton radiotherapy for patients with
potentially resectable retroperitoneal sarcoma. (Pre-operative cohort) IV. To assess acute
side effects from irradiation using proton beam therapy and dose/volume constraints that are
derived from conventional radiotherapy. (Postoperative cohort)
SECONDARY OBJECTIVES:
I. To assess the clinical effectiveness of proton radiotherapy for retroperitoneal sarcoma.
II. To determine the long-term toxicity of proton radiotherapy to the abdomen and pelvis
region.
III. To monitor for effects of proton treatment on tumor and normal tissues using
radiographic imaging (both cohorts) or ex-vivo analysis of tissue samples (preoperative
cohort only).
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