Training in Goal-directed Attention Regulation for Individuals With Brain Injury



Status:Completed
Conditions:Hospital, Neurology
Therapuetic Areas:Neurology, Other
Healthy:No
Age Range:18 - 75
Updated:10/22/2017
Start Date:September 2009
End Date:April 2017

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Plasticity in Brain Network to Enhance Cognitive Rehabilitation

Brain injuries affect the lives of numerous Veterans. This study examines how the brain is
affected by injury and how rehabilitation training for attention dysfunction may change brain
functioning.

Traumatic brain injuries (TBI) are a leading cause of long-term disability among combat
Veterans. The most common and persistent sequelae after TBI are cognitive-behavioral deficits
in 'executive control' and 'attention' functions. Such abnormalities may directly contribute
to poor long-term outcomes as well as impede rehabilitation of dysfunction in other cognitive
and motor domains. Effective treatments would potentially make a major impact in improving
functional outcomes, but consistently effective treatments are not available. The overall
goal of this research is to improve the investigators' understanding of plasticity in brain
function after TBI and to develop improved cognitive neurorehabilitation treatments. The
intervention involves individual and group-based training in cognitive skills.

Inclusion Criteria:

- history of traumatic brain injury

- greater than 1 week from injury

- residual dysfunction related to attention and executive control

Exclusion Criteria:

- aphasia

- active illicit drug use

- severe depression

- contraindications to MRI scanning
We found this trial at
1
site
Sacramento, California 95655
Principal Investigator: Mark D'Esposito, MD
Phone: 415-750-2011
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from
Sacramento, CA
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