A Study to Test Lung Function After Radiation Therapy
| Status: | Completed |
|---|---|
| Conditions: | Lung Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/30/2013 |
| Start Date: | June 2009 |
| End Date: | December 2013 |
| Contact: | Jane Hershberger, RN, BSN |
| Email: | jane-hershberger@uiowa.edu |
| Phone: | (319) 384-7912 |
Quantifying Radiation Induced Changes in Pulmonary Function in Irradiated and Non-irradiated Lung Tissue
It is known that radiation damages lung tissue. New human studies at University of Iowa show
that the radiation damage is not as expected. The purpose of this study is to document lung
function using four-dimensional computed tomography (CT) and quantify changes three months
after radiation therapy for malignant lung disease.
Inclusion Criteria:
- Histological diagnosis of small cell or non-small cell lung cancer or metastatic
tumor to the lung being scheduled for localized radiation therapy (including
radiosurgery)
- No prior or future planned surgery for the treatment of the lung cancer.
- Age ≥ 18 years
- Karnofsky 60%
- Not pregnant.
- Ability to understand and the willingness to sign a written informed consent document
- Ability and willingness to participate in breathing training and compliance wiht
breathing apparatus so that radiation doses are optimally linked to 4D-CT images
- Ability to tolerate CT contrast
Exclusion Criteria:
- No prior thoracic radiotherapy will be permitted
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements
- Pregnant women
- Severe COPD that requires chronic prednisone or multiple inhalers
- Underlying collagen vascular disease or intrinsic lung disease that could complicate
expected sequelae of radiation (idiopathic pulmonary fibrosis, Wegener's
granulomatosis)
- Oxygen dependence at baseline
- Recent lung surgery or abdominal surgery (within 3 weeks) that would compromise
respiratory pattern.
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