Vitamin D, Insulin Sensitivity, and Vascular Associations in Adolescents
| Status: | Archived |
|---|---|
| Conditions: | Cardiology, Endocrine |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Endocrinology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | December 2009 |
| End Date: | November 2012 |
Serum 25-hydroxyvitamin D, Vascular Functioning, and Insulin Sensitivity in Adolescent Girls [The DIVA Study (Vitamin D, Insulin, and Vascular Associations)] (Pediatric Physician Training in Translational Research)
The overall objectives of this study are to examine the relationships between circulating
vitamin D, insulin sensitivity, and multiple indices of vascular function and to examine
whether vitamin D deficiency in AA is responsible for ethnic differences in insulin
sensitivity and hypertension in AA and EA, as well as mechanisms underlying the association
between insulin resistance and blood pressure. We hypothesize that 1) serum 25(OH)D is
associated with insulin sensitivity and vascular functioning, independent of adiposity, 2)
lower insulin sensitivity and vascular functioning in AA relative to EA is due to lower
circulating 25(OH)D in AA, and 3) the relationship between insulin resistance and vascular
dysfunction is mediated by 25(OH)D.
Acronyms: African American (AA), European American (EA), Serum 25-hydroxy vitamin D
(25()H)D, Body mass index (BMI), Alabama (AL).
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