Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA)

The purpose of this study is to compare different medication combinations used in a
periarticular injection after total knee replacement surgery. A periarticular injection is
an injection that is given into the tissues surrounding the knee joint. The injection is
given while the patient is still in surgery.

The study will compare the level of pain management, length of hospital stay, range of
motion and side effects from subjects receiving one of four different combinations of
medication in a periarticular injection. The medications used in the injections are
approved medications routinely used for pain management.

Approximately 200 subjects will participate in this study. The surgeon, study personnel, and
patients will be blinded to the combination of medications each patient receives. The
pharmacist will prepare the 4 different combinations of medications, randomize each patient
to the particular combination of medications, and maintain the study drug documentation.