Executive Dysfunction and Suicide in Psychiatric Outpatients and Inpatients
| Status: | Completed |
|---|---|
| Conditions: | Hospital, Neurology, Psychiatric |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology, Other |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 5/5/2014 |
| Start Date: | June 2010 |
| End Date: | March 2014 |
| Contact: | Lisa A Brenner, PhD |
| Email: | lisa.brenner@va.gov |
| Phone: | (303) 399-8020 |
Those with traumatic brain injury (TBI) are at increased risk for suicidal behavior, and
suicidality is associated with executive dysfunction. In the aim of highlighting an
important risk factor, this study will assess decision making in the context of an
interaction between suicide and TBI. Findings will also allow for exploratory analyses aimed
at identifying associations between performance on measures of executive functioning and
psychological distress. The long-term objective of this study is to increase understanding
regarding executive dysfunction, as a multidimensional construct, with the ultimate goal of
conceptualizing assessment tools and interventions aimed at decreasing suicidality in the
at-risk population of veterans with a history of TBI.
suicidality is associated with executive dysfunction. In the aim of highlighting an
important risk factor, this study will assess decision making in the context of an
interaction between suicide and TBI. Findings will also allow for exploratory analyses aimed
at identifying associations between performance on measures of executive functioning and
psychological distress. The long-term objective of this study is to increase understanding
regarding executive dysfunction, as a multidimensional construct, with the ultimate goal of
conceptualizing assessment tools and interventions aimed at decreasing suicidality in the
at-risk population of veterans with a history of TBI.
Recent studies indicate that veterans who engage in suicidal behavior have a history of
traumatic brain injury (TBI), and veterans with a history of TBI engage in suicidal
behavior. Existing research also suggests an association between suicidality and executive
dysfunction (e.g., impaired decision making). To date a clearly defined study has not been
conducted to explore the relationship between executive dysfunction as a multidimensional
construct (i.e., decision making, impulsivity, concept formation, and aggression) and
suicidal behavior in the vulnerable population of those with a history of moderate to severe
TBI. Increased understanding regarding this at-risk population is necessary to facilitate
the creation of appropriate assessment strategies and interventions. This study will assess
decision making in the context of an interaction between suicide and TBI. Findings will also
allow for exploratory analyses aimed at identifying associations between performance on
measures of executive functioning and psychological distress. Toward this end, the present
study seeks to compare test performance among four well-defined groups of veterans: (1)
those with moderate to severe TBI and a history of suicidal behavior; (2) those with
moderate to severe TBI and no history of suicidal behavior; (3) those with no TBI and a
history of suicidal behavior; (4) and those with no TBI and no history of suicidal behavior.
This grant proposal is in direct support of the Rehabilitation Research and Development goal
of maximizing functional recovery in those with TBI by potentially: 1) increasing
clinicians' ability to identify neuropsychological correlates of suicidal behavior for those
with moderate to severe TBI; 2) identifying psychometrically sound measures of executive
functioning that correspond to real-life behaviors that impact treatment response and
recovery; 3) facilitating the creation of innovative assessment techniques and psychosocial
interventions (e.g., safety planning) to minimize complications in the management of
suicidal behavior due to TBI-related impairments; and 4) creating a basis for further and
much-needed research in this area. Ultimately, findings from this study would both
contribute to clinicians' ability to identify veterans with TBI who are at risk for suicidal
behavior, and create a foundation on which to base further research regarding the
relationships between cognition, emotional distress, and suicidality in TBI survivors.
traumatic brain injury (TBI), and veterans with a history of TBI engage in suicidal
behavior. Existing research also suggests an association between suicidality and executive
dysfunction (e.g., impaired decision making). To date a clearly defined study has not been
conducted to explore the relationship between executive dysfunction as a multidimensional
construct (i.e., decision making, impulsivity, concept formation, and aggression) and
suicidal behavior in the vulnerable population of those with a history of moderate to severe
TBI. Increased understanding regarding this at-risk population is necessary to facilitate
the creation of appropriate assessment strategies and interventions. This study will assess
decision making in the context of an interaction between suicide and TBI. Findings will also
allow for exploratory analyses aimed at identifying associations between performance on
measures of executive functioning and psychological distress. Toward this end, the present
study seeks to compare test performance among four well-defined groups of veterans: (1)
those with moderate to severe TBI and a history of suicidal behavior; (2) those with
moderate to severe TBI and no history of suicidal behavior; (3) those with no TBI and a
history of suicidal behavior; (4) and those with no TBI and no history of suicidal behavior.
This grant proposal is in direct support of the Rehabilitation Research and Development goal
of maximizing functional recovery in those with TBI by potentially: 1) increasing
clinicians' ability to identify neuropsychological correlates of suicidal behavior for those
with moderate to severe TBI; 2) identifying psychometrically sound measures of executive
functioning that correspond to real-life behaviors that impact treatment response and
recovery; 3) facilitating the creation of innovative assessment techniques and psychosocial
interventions (e.g., safety planning) to minimize complications in the management of
suicidal behavior due to TBI-related impairments; and 4) creating a basis for further and
much-needed research in this area. Ultimately, findings from this study would both
contribute to clinicians' ability to identify veterans with TBI who are at risk for suicidal
behavior, and create a foundation on which to base further research regarding the
relationships between cognition, emotional distress, and suicidality in TBI survivors.
Inclusion Criteria:
- Age between 18 and 65
- Ability to provide adequate effort (CARB score of Type 1 or 2)
- Determination of positive or negative history of moderate or severe TBI
- Determination of positive or negative history of suicidal behavior
- Ability to adequately respond to questions regarding the informed consent procedure
Exclusion Criteria:
- Diagnosis of neurological conditions other than moderate or severe TBI
- Inability to adequately respond to questions regarding the informed consent procedure
- Inability to provide adequate effort (CARB score of Type 3 or 4)
- History of a psychotic or bipolar I mood disorder
- History of drug or alcohol abuse in the past 7 days
- Participating in another study in which the results of this study may be impacted
- History of non-alcohol substance abuse within the last 30 days as identified on the
SCID substance use module
- History of same-day drug or alcohol abuse as identified on the UWRAP
pre-administration questionnaire Veterans who report using substances the day of the
study visit will be placed on hold and will be rescreened in 30 and 60 days
- History of mild TBI only
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