Same-day, Reduced Volume Bowel Preparation
| Status: | Archived |
|---|---|
| Conditions: | Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | January 2010 |
| End Date: | December 2010 |
Evaluating the Effectiveness of a Same-day, Reduced Volume Polyethylene Glycol + Electrolyte Solution (PEG-ELS) Bowel Preparation for Afternoon Colonoscopies
We seek to evaluate whether a same day, reduced liquid volume (2liters) polyethylene glycol
(PEG-ELS) bowel preparation can achieve adequate colon cleansing in patients scheduled for
afternoon colonoscopies. The primary outcome will be adequacy of the bowel preparation.
Secondary outcomes will include Boston Bowel Preparation Scale score, patient compliance
with completing the preparation, tolerability of the preparation, willingness to repeat the
preparation, side effects, duration of procedure (endoscope insertion and withdrawal times),
and polyp detection.
The diagnostic accuracy of colonoscopy depends on the quality of the preparation. The
adequacy of the preparation determines whether complete visualization of the mucosa and
identification of pathologic lesions is achieved. For reasons that are not entirely clear,
colonoscopies scheduled in the afternoon have been identified as a risk factor for having an
inadequate preparation. Standard bowel preparation regimens at BMC include polyethylene
glycol- electrolyte solutions (PEG-ELS) in full (four liters) and reduced (two liters)
forms. These laxatives are typically administered either the evening prior to the
colonoscopy or in "split dose" (a portion the evening before and a portion the morning of
the colonoscopy). The percent of failed colonoscopies due to a fair/poor preparation in our
endoscopy unit is 17-20%. Our trial seeks to establish the efficacy and safety of a reduced
volume PEG-ELS laxative given on the day of the colonoscopy.
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Boston Med Center Boston Medical Center (BMC) is a 496-bed academic medical center located in...
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