Early Menopause Hormone Treatment and Cognition
| Status: | Archived |
|---|---|
| Conditions: | Postmenopausal Syndrome, Women's Studies |
| Therapuetic Areas: | Endocrinology, Reproductive |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | April 2009 |
| End Date: | March 2011 |
Hormones and Cognitive Processing in Early Postmenopausal Women
The objective of this study is to evaluate the neurobiological effects of hormone therapy
(HT) in healthy early postmenopausal women. The studies proposed in this project seek to
define the association between different hormone forms (estradiol only and progesterone
only) versus placebo on brain functional measures. The functional measures will include the
performance of the volunteers on a comprehensive neuropsychological testing battery, and the
brain functional responses to episodic memory (verbal and non-verbal) challenges as well as
emotional processing determined with fMRI.
Specific Aims
Aim 1. To examine the effects of estradiol alone on brain functioning in early
post-menopausal women during verbal and non-verbal cognitive tasks.
Hypothesis: It is expected that with estradiol treatment brain activation will be more
prominent in the hippocampus and prefrontal cortical areas compared to placebo. The
magnitude of activation in these regions will be positively correlated with task performance
in the scanner and with the results of neuropsychological tests assessing verbal and
non-verbal delayed recall.
Aim 2. To determine the effects of progesterone alone on brain functioning in early
postmenopausal women during verbal and non-verbal cognitive tasks.
Hypothesis: It is expected that with progesterone treatment brain activation in the
hippocampus and prefrontal cortical areas will be decreased compared to both the placebo
condition (within subjects) and the estradiol condition (between subjects). Interindividual
variations in the magnitude of activation in these regions will be positively correlated
with task performance in the scanner and with the results of neuropsychological tests
assessing verbal and non-verbal delayed recall.
Aim 3. To determine the individual effects of estradiol and progesterone on brain
functioning in early postmenopausal women during emotional processing stimuli.
Hypothesis: During negative stimuli estradiol-treated women compared to placebo group, are
expected to have increased activity in the amygdala, posterior cingulate, and orbitofrontal
cortex, while in progesterone-treated women compared to placebo, decreased activity is
expected in these brain regions.
We found this trial at
1
site
1500 E Medical Center Dr
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
(734) 936-4000
University of Michigan Health Systems The University of Michigan is home to one of the...
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