Mapping Auricular Vagus Nerve Circuitry
| Status: | Recruiting |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 9/13/2018 |
| Start Date: | February 1, 2017 |
| End Date: | May 2020 |
| Contact: | Rowan Staley, B.A. |
| Email: | rstaley@mgh.harvard.edu |
| Phone: | 617-643-9790 |
Auricular Vagal Nerve Stimulation for Gastric and Brain Outcomes
This study will determine how vagus nerve stimulation affects human brain, stomach, and
autonomic activity.
autonomic activity.
Scientific research into the basic mechanisms underlying neuromodulation is relatively recent
and incomplete. The purpose of the proposed study is to determine how a form of
neuromodulation, transcutaneous vagus nerve stimulation, which is non-invasive and
non-painful, affects human brain and autonomic activity. We will accomplish this by
integrating whole brain functional MRI (fMRI) methodologies with gastric MRI and
physiological monitoring.
This study will comprise 2 functional magnetic resonance imaging (fMRI) brain-gut scans and 2
behavioral visits consisting of a nutrient drink test, all while receiving the
neuromodulation with varying parameters. Participants will also have their heart rate,
breathing, and gastric activity monitored during all visits.
and incomplete. The purpose of the proposed study is to determine how a form of
neuromodulation, transcutaneous vagus nerve stimulation, which is non-invasive and
non-painful, affects human brain and autonomic activity. We will accomplish this by
integrating whole brain functional MRI (fMRI) methodologies with gastric MRI and
physiological monitoring.
This study will comprise 2 functional magnetic resonance imaging (fMRI) brain-gut scans and 2
behavioral visits consisting of a nutrient drink test, all while receiving the
neuromodulation with varying parameters. Participants will also have their heart rate,
breathing, and gastric activity monitored during all visits.
Inclusion Criteria:
- Right-handed
Exclusion Criteria:
- Any condition contraindicating an fMRI brain scan
- Any neurological or psychiatric disorders
- Any pain syndromes
We found this trial at
1
site
185 Cambridge Street
Boston, Massachusetts 02114
Boston, Massachusetts 02114
617-724-5200
Principal Investigator: Vitaly Napadow, PhD
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