Improving Muscle for Functional Independence Trial
| Status: | Completed |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 65 - 79 |
| Updated: | 8/3/2018 |
| Start Date: | February 2010 |
| End Date: | May 2014 |
Aging is associated with declines in muscle strength, power, and overall functional ability
that lead to disability and loss of independence. Furthermore, the existing high prevalence
of obesity in the elderly is greatly exacerbating these aging-related declines in function.
To date, regular exercise, especially resistance exercise, is the only known treatment to
consistently improve muscle function and perhaps delay the onset of disability. However, not
all individuals experience the same magnitude of benefit from a given exercise stimulus, and
accumulating data show that obesity limits muscle adaptations to chronic exercise.Therefore,
the proposed study is designed to determine the effects of caloric restriction on
improvements in skeletal muscle function in response to RT.
that lead to disability and loss of independence. Furthermore, the existing high prevalence
of obesity in the elderly is greatly exacerbating these aging-related declines in function.
To date, regular exercise, especially resistance exercise, is the only known treatment to
consistently improve muscle function and perhaps delay the onset of disability. However, not
all individuals experience the same magnitude of benefit from a given exercise stimulus, and
accumulating data show that obesity limits muscle adaptations to chronic exercise.Therefore,
the proposed study is designed to determine the effects of caloric restriction on
improvements in skeletal muscle function in response to RT.
Design Overview:
This is a 5-month randomized trial in 130 older, overweight or obese, sedentary men and
women. Phase 1 involves recruitment and screening followed by baseline research testing
(Phase 2). Next, subjects will be randomly assigned to one of two 5-month treatments (Phase
3): RT intervention alone (RT) or to an RT with caloric restriction (RT+CR) intervention.
Subjects will return for visits the completion of their 5 month intervention. A subset of
participants (n=30) will return for an 18 month follow up.
Interventions:
Resistance training+ Caloric Restriction:Participants assigned to RT+CR group will be
instructed to follow a hypocaloric diet (-600 kcal/d) for 20 weeks, as well as the resistance
training program noted below.In addition, all participants will be provided with a daily
calcium (1200 mg/d) and vitamin D (800 IU/d) supplement.The intervention will incorporate
meal replacements, nutrition education, and lifestyle behavior modifications.
Resistance training: The maximal weight that can be lifted with correct form in a single
repetition (1RM) will be used to prescribe intensity. Strength testing will be repeated every
4 wks and the training loads adjusted so that they are consistent with the 70% 1RM goal.
Participants will exercise 3 d/wk on Nautilus resistance machines, under the supervision of
two exercise leaders who are trained in basic life support and in emergency management
procedures. All exercise will take place at Wake Forest University's Department of Health and
Exercise Science Clinical Research Center (CRC). Participants will exercise in small groups
which will allow a rotation/rest between machines and enhance the social environment. Heart
rate and blood pressure will be measured before and after each session. Subjects will warm-up
by walking or cycling for 5 minutes at a slow pace followed by large muscle flexibility
exercises. The interventionists will ensure that participants adjust the equipment
appropriate to their body size and complete the exercises with correct form. Training
sessions will end with a cool-down by walking or cycling for 5 minutes at a slow pace
followed by light stretching.
This is a 5-month randomized trial in 130 older, overweight or obese, sedentary men and
women. Phase 1 involves recruitment and screening followed by baseline research testing
(Phase 2). Next, subjects will be randomly assigned to one of two 5-month treatments (Phase
3): RT intervention alone (RT) or to an RT with caloric restriction (RT+CR) intervention.
Subjects will return for visits the completion of their 5 month intervention. A subset of
participants (n=30) will return for an 18 month follow up.
Interventions:
Resistance training+ Caloric Restriction:Participants assigned to RT+CR group will be
instructed to follow a hypocaloric diet (-600 kcal/d) for 20 weeks, as well as the resistance
training program noted below.In addition, all participants will be provided with a daily
calcium (1200 mg/d) and vitamin D (800 IU/d) supplement.The intervention will incorporate
meal replacements, nutrition education, and lifestyle behavior modifications.
Resistance training: The maximal weight that can be lifted with correct form in a single
repetition (1RM) will be used to prescribe intensity. Strength testing will be repeated every
4 wks and the training loads adjusted so that they are consistent with the 70% 1RM goal.
Participants will exercise 3 d/wk on Nautilus resistance machines, under the supervision of
two exercise leaders who are trained in basic life support and in emergency management
procedures. All exercise will take place at Wake Forest University's Department of Health and
Exercise Science Clinical Research Center (CRC). Participants will exercise in small groups
which will allow a rotation/rest between machines and enhance the social environment. Heart
rate and blood pressure will be measured before and after each session. Subjects will warm-up
by walking or cycling for 5 minutes at a slow pace followed by large muscle flexibility
exercises. The interventionists will ensure that participants adjust the equipment
appropriate to their body size and complete the exercises with correct form. Training
sessions will end with a cool-down by walking or cycling for 5 minutes at a slow pace
followed by light stretching.
Inclusion Criteria:
- BMI=27-34.9 kg/m2
- No resistance training for past 6 mos
- Normal cognitive function (MMSE >24)
- No contraindications for participation in weight loss or resistance exercise including
severe arthritis or musculoskeletal disorders, knee or hip replacement or spinal
surgery in past year
- No broken bones in the past 6 months
- Able to provide own transportation to study visits and intervention
- Not involved in any other research study and not undergoing physical therapy
- Not dependent on a cane or walker
Exclusion Criteria:
- Weight loss or gain (±5%) in past 6 months
- Body mass >136 kg (DXA limit)
- Current smoker (No nicotine within past year) or evidence of alcohol or drug abuse
- Insulin dependent or uncontrolled diabetes (FBG >140 mg/dL)
- Uncontrolled hypertension (BP>180/100 mmHg)
- Abnormal kidney function or liver blood tests
- Past or current cardiovascular disease, including uncontrolled angina or dysrhythmia,
hypertrophic cardiomyopathy, congestive heart failure, PAD, stroke, history of
myocardial infarction, use of defibrillator or major heart surgery, or deep vein
thrombosis or pulmonary embolus
- Past or current respiratory disease (requiring steroid treatment or supplemental
oxygen)
- Past or current clinical diagnoses of neurological or hematological disease
- Use of any medications that could influence study variables (growth/steroid hormones,
prescription anti-inflammatory medications, or beta blockers, Coumadin or any other
blood thinner, including Plavix, Ticid, and Aggrenox)
- Cancer requiring treatment in past 2 years, except non-melanoma skin cancers
- Clinically evident edema or anemia
We found this trial at
1
site
1 Medical Center Blvd
Winston-Salem, North Carolina 27157
Winston-Salem, North Carolina 27157
336-716-2011
Wake Forest University Health Sciences Welcome to Wake Forest Baptist Medical Center, a fully integrated...
Click here to add this to my saved trials
