To Investigate the Role of Upstream High Dose Statin in STEMI

Inclusion Criteria:

1. Any patient of 25 to 90 years of age admitted or transferred to Western Pennsylvania
Hospital or Allegheny General Hospital with a diagnosis of STEMI undergoing emergent
percutaneous intervention (PCI) to the culprit coronary artery. STEMI is defined as
greater than 1mm ST segment elevation on electrocardiogram.

2. Elevated cardiac biomarkers (troponin-T > 0.03ng/ml, CKMB>5ng/mL, or ck>170 U/l).

Exclusion Criteria:

1. Known history of liver disease defined as cirrhosis, alcoholic liver disease, Non
alcoholic steatohepatitis, hepatitis or any causes of liver failure.

2. Renal failure with creatinine >3mg/dL

3. Known history of liver or muscle disease such as rheumatologic myopathies, history of
myositis, hepatitis, and hepatic cancer.

4. Cardiovascular arrest and shock.