Glutamine Supplementation in Cystic Fibrosis
| Status: | Completed |
|---|---|
| Conditions: | Infectious Disease, Pulmonary |
| Therapuetic Areas: | Immunology / Infectious Diseases, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/27/2013 |
| Start Date: | February 2010 |
| End Date: | February 2011 |
| Contact: | Thomas Ziegler, MD |
| Email: | tzieg01@emory.edu |
| Phone: | 404-727-7351 |
Glutamine Supplementation and Immunity in Adults With Cystic Fibrosis
Patients with cystic fibrosis develop frequent and potentially life-threatening lung
infections. Recent studies suggest that the nutrient "glutamine" may help the body fight off
infection. Glutamine is an amino acid; a type of nutrient the body requires to build muscle.
It is one of the building blocks of protein. During an illness, blood levels of glutamine
tend to be lower than normal. Also, many patients with cystic fibrosis have difficulty
getting normal levels of nutrients from food. The aim of this study is to see if patients
with cystic fibrosis have low levels of glutamine when they experience an infection, and
whether a dietary glutamine supplement taken daily for three months can raise these levels.
We also want to see if this supplement can improve other blood markers of immunity (the
body's ability to defend itself from infection). We hope to enroll 40 people with cystic
fibrosis who experience a lung infection, over a one year period, into this study.
Inclusion Criteria:
- Adult patients (≥ 18 years of age) with cystic fibrosis who give informed consent
- Patients must have a clinically diagnosed pulmonary exacerbation at time of
enrollment, characterized by clinical requirement for oral or intravenous antibiotics
associated with pulmonary symptoms such as increased cough or decreased forced
expiratory volumes (FEV1)
- Participants must agree to provide phlebotomy samples and complete all study protocol
at presentation and at return visits
Exclusion Criteria:
- Any patients taking specific glutamine supplements within 30 days of enrollment
- Pregnant or lactating women
- Patients involved in any other research protocol involving intake of a study drug, in
the last 60 days.
- Patients who are chronically immunosuppressed due to drugs or immunosuppressive
illness other than CF (e.g. HIV/AIDS, chronic autoimmune disease)
- Patients receiving hemodialysis or with creatinine >2.5mg/dL
- Patients with liver failure from any cause
- Patients with a history of cancer within the past 12 months or currently receiving
anti-neoplastic therapy.
- Patients with a history of seizures
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