Stimulation of Sensation and Improvement in Swallowing Using Oral Capsaicin
| Status: | Completed |
|---|---|
| Conditions: | Gastroesophageal Reflux Disease , Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/30/2013 |
| Start Date: | October 2009 |
| End Date: | October 2012 |
| Contact: | Peter A Belafsky, MD, Ph.D. |
| Email: | peter.belafsky@ucdmc.ucdavis.edu |
| Phone: | 916-734-7470 |
This is a research study to learn more about whether capsaicin, a natural ingredient of
chili peppers that makes them taste "hot", can improve swallowing function. The purpose of
this study is to evaluate whether sucking on a capsaicin lozenge improves sensation in the
throat enough to improve swallowing function.
Swallowing problems are encountered frequently in primary practice and in the hospital
setting. The list of possible causes is large, ranging from strokes and neurological
disease through to complications of cancer treatment, acid reflux, and surgery. Many
patients have a reduced ability to feel food and fluid (reduced sensation) within the throat
(pharynx) and this leads to inability to manipulate food and fluids in the correct manner.
This can produce a variety of swallowing problems such as choking on foods and fluids,
regurgitation, aspiration, weight loss, malnutrition and poor quality of life.
Treatment is largely directed at rehabilitation of muscle power and education about safe
swallowing techniques or positioning that limits food and fluid entering the airway. A
novel approach is to try to improve sensation within the pharynx so that patients can feel
substances present and then manipulate them in a more appropriate and safe manner. In this
regard capsaicin, a nutritional supplement derived from peppers, has shown a stimulatory
effect on sensory nerves and an ability to improve the swallowing reflex (Ebihara et al.,
2005). Although studies have shown that capsaicin can improve the swallowing reflex, data
regarding improvement in swallowing function is lacking. Using a small dose of capsaicin
administered as a lozenge, we hope to stimulate sensation within the pharynx enough to
improve physical swallowing measures on a contrast swallow study. This method of
application is comfortable, easy and directed to the site of action.
Inclusion Criteria:
- Patients older than 18 years of age
- Patients with the following condition: dysphagia, globus, gastroesophageal reflux,
neurological disease affecting swallowing or any other condition requiring dynamic
swallow study
- Patients willing to provide written informed consent for their participation in the
study
Exclusion Criteria:
- Patients unable to complete a full dynamic swallow study protocol
- Patients enrolled in another investigational clinical trial that interferes with any
testing or testing results
- Patients who are pregnant
- Patients with known sensitivities or allergies to capsaicin or peppers, or
nightshades (tomato, bell pepper, eggplant) or latex
- Patients who are prisoners
- Patients who are unable to keep a capsaicin lozenge in their mouth safely for 5
minutes
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