Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)
| Status: | Terminated |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/5/2018 |
| Start Date: | September 2009 |
| End Date: | September 2015 |
A Double-blinded Randomized Controlled Trial of Dexmedetomidine Versus Propofol for Sedation in Mechanically Ventilated Medical Intensive Care Unit Patients.
This is a randomized controlled trial to compare propofol to dexmedetomidine for prolonged
sedation (> 24 hours) in critically ill patients who require mechanical ventilation.
sedation (> 24 hours) in critically ill patients who require mechanical ventilation.
Mechanically ventilated critically ill patients are routinely given sedative and analgesic
medications to relieve pain and anxiety associated with intubation, mechanical ventilation,
and critical care in general. While integral in minimizing discomfort, these medications may
increase mechanical ventilation time, the duration of intensive care unit (ICU) stay, ICU
complications (e.g. delirium, ventilator associated pneumonia, venous thromboembolism), the
morbidity associated with critical illness, and patient mortality. This study compares two
sedative medications that have been used in patients who require a mechanical ventilator.
Enrolled patients will be randomly assigned to receive propofol or dexmedetomidine for
sedation while they require ventilatory support. All patients will also receive the pain
medication fentanyl as needed.
medications to relieve pain and anxiety associated with intubation, mechanical ventilation,
and critical care in general. While integral in minimizing discomfort, these medications may
increase mechanical ventilation time, the duration of intensive care unit (ICU) stay, ICU
complications (e.g. delirium, ventilator associated pneumonia, venous thromboembolism), the
morbidity associated with critical illness, and patient mortality. This study compares two
sedative medications that have been used in patients who require a mechanical ventilator.
Enrolled patients will be randomly assigned to receive propofol or dexmedetomidine for
sedation while they require ventilatory support. All patients will also receive the pain
medication fentanyl as needed.
Inclusion Criteria:
- >18 years old
- mechanically ventilated through endotracheal tube
- anticipated need for ventilation > 48 hours
- requiring sedative/analgesic medication
Exclusion Criteria:
- on mechanical ventilator > 96 hours
- primary neurologic disease
- post cardiac arrest
- do not speak English (assessment only English language validated)
- pregnancy or lactation
- active myocardial ischemia
- second or third degree heart block
- pancreatitis
- elevated serum triglycerides (> 400 mg/dL)
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