A Comprehensive Study to Isolate Tumor-initiating Cells From Human Epithelial Malignancies
| Status: | Completed |
|---|---|
| Conditions: | Skin Cancer, Cancer, Cancer, Bladder Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | December 2013 |
| End Date: | December 2014 |
We hypothesize that all human malignancies harbour a subpopulation of tumor initiating
cells/cancer stem cells (CSCs) that drives tumor development and potentially recurrence or
metastasis of the disease. The primary aim of this study is to develop strategies for
prospective isolation/enrichment of CSCs from human tumors of different tissue origins. In
addition, we will characterize the signaling pathways and/or tumor specific antigens that
are specific for CSCs, in order to specifically target these CSCs as the endpoint of this
study.
cells/cancer stem cells (CSCs) that drives tumor development and potentially recurrence or
metastasis of the disease. The primary aim of this study is to develop strategies for
prospective isolation/enrichment of CSCs from human tumors of different tissue origins. In
addition, we will characterize the signaling pathways and/or tumor specific antigens that
are specific for CSCs, in order to specifically target these CSCs as the endpoint of this
study.
Inclusion Criteria:N/A. We will recruit all non-melanoma skin and bladder cancer patients
that are recommended for surgical removal of tumor tissues. This includes patients from
all ages, gender and ethnicity background. Our sample collection criteria based on the
tumor size of individual (e.g. tumor samples will only be collected if it will not affect
the pathological diagnosis or treatment procedures of patients).
Exclusion Criteria:N/A
We found this trial at
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Stanford University School of Medicine Vast in both its physical scale and its impact on...
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