Functional Neuroimaging of Cortical Plasticity in the Human Visual System



Status:Recruiting
Conditions:Neurology, Ocular
Therapuetic Areas:Neurology, Ophthalmology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:January 2009
End Date:December 2017
Contact:Stelios M Smirnakis, MD, PhD
Email:ssmirnakis@cns.bcm.edu
Phone:713-798-3972

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Trial Summary
Trial Overview
Inclusion Criteria
The study's objective is to measure changes in human visual cortex organization that may
arise as a result of injury to the visual pathways. Subjects with retinal or cortical injury
will be studied and compared to appropriate controls. Functional magnetic resonance imaging
methods are used to monitor cortical topography in time. The main aims of the study are to
determine: 1) what are the patterns of cortical reorganization that are seen spontaneously
after injury, and 2) whether rehabilitative training can promote adaptive reorganization
enhancing recovery.


Inclusion Criteria:

- Stable lesion of the visual pathways resulting in a visual field scotoma.

Exclusion Criteria:

- Inability to undergo magnetic resonance imaging,

- Inability to comply with basic instructions,

- Inability to perform the behavioral tasks required,

- Patients with chronic progressive neurological or psychiatric disorders,

- Patients that are pregnant, or breast feeding.
We found this trial at
2
sites
Baylor College of Medicine
1200 Moursund Street
Houston, Texas 77030
(713) 798-4951
Principal Investigator: Stelios M Smirnakis, MD, PhD
Phone: 713-798-3972
Baylor College of Medicine Baylor College of Medicine in Houston, the only private medical school...
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Max Planck Institute for Biological Cybernetics
Tuebingen,
Principal Investigator: Ulrich Schiefer, MD
Phone: 713-798-3972
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