Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Brain Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 3 - 25 |
| Updated: | 3/31/2019 |
| Start Date: | April 2010 |
| End Date: | November 2021 |
Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma: An Assessment of Acute Toxicity and Long Term Neurocognitive, Neuroendocrine and Ototoxicity Outcomes
There are two types of external radiation treatments (proton beam and photon beam). As part
of the participant's treatment, they will receive radiation to the entire central nervous
system (CNS); this is known as craniospinal irradiation (CSI). In the past, photon radiation
therapy has been used for CSI. In this study we will be examining the effects of proton beam
radiation therapy. Studies have suggested that this kind of radiation can cause less damage
to normal tissue than photon radiation therapy. The physical characteristics of proton beam
radiation let the doctor safely deliver the amount of radiation delivered to the tumor that
is normally delivered through standard therapy but spare more normal tissue in the process.
of the participant's treatment, they will receive radiation to the entire central nervous
system (CNS); this is known as craniospinal irradiation (CSI). In the past, photon radiation
therapy has been used for CSI. In this study we will be examining the effects of proton beam
radiation therapy. Studies have suggested that this kind of radiation can cause less damage
to normal tissue than photon radiation therapy. The physical characteristics of proton beam
radiation let the doctor safely deliver the amount of radiation delivered to the tumor that
is normally delivered through standard therapy but spare more normal tissue in the process.
- Before beginning radiation therapy, participants will have scans done in order to
prepare for the radiation treatment. Doctors will use information gathered from these
scans to plan the best way to deliver radiation to the tumor.
- The following procedures will be performed either before or during the radiotherapy:
Hearing exam; neurocognitive exam; blood tests and cerebral spinal fluid test.
- Not everyone who participates in this study will receive the same amount of proton
radiation therapy. The length of time and amount of radiation received will depend upon
the condition of the participant's disease. Radiation treatment will be given once a
day, 5 days a week (Monday-Friday). The overall treatment course will be approximately 6
weeks.
prepare for the radiation treatment. Doctors will use information gathered from these
scans to plan the best way to deliver radiation to the tumor.
- The following procedures will be performed either before or during the radiotherapy:
Hearing exam; neurocognitive exam; blood tests and cerebral spinal fluid test.
- Not everyone who participates in this study will receive the same amount of proton
radiation therapy. The length of time and amount of radiation received will depend upon
the condition of the participant's disease. Radiation treatment will be given once a
day, 5 days a week (Monday-Friday). The overall treatment course will be approximately 6
weeks.
Inclusion Criteria:
- Participants must have undergone biopsy or attempted surgical resection and must have
histologically confirmed medulloblastoma or pineoblastoma.
- Participants may have had a gross total resection, sub-total resection or biopsy only.
- For patients with no prior chemotherapy, treatment must start within 35 days of
definitive surgery or as indicated if enrolled on therapeutic study
- Age range between 3 and 25 at the time of enrollment
- Life expectancy of greater than 3 months
- Blood laboratory values as outlined in the protocol
- Women of child-bearing potential and men must agree to use adequate contraception
prior to study entry and for the duration of study participation
Exclusion Criteria:
- Patients with more than one previous chemotherapy regimen
- Patients with recurrent or progressive disease after one or more regimens of
pre-radiation chemotherapy
- Patients with prior radiation therapy
- Any major uncontrolled or poorly controlled intercurrent illness that would limit
compliance with study requirements
- Pregnant women
We found this trial at
2
sites
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185 Cambridge Street
Boston, Massachusetts 02114
Boston, Massachusetts 02114
617-724-5200
Principal Investigator: Torunn I Yock, MD
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