Effects of Endoscopic Sinus Surgery for Chronic Sinusitis on Asthma Control

Inclusion Criteria:

- Inclusion criteria: General

1. 18 years of age or older

2. Women need one of the following: negative pregnancy test or suitable birth
control or post-menopausal status

3. Informed consent and ability to comply with study procedures

4. Patients must meet inclusion criteria for both asthma and sinus disease.

Inclusion criteria: Asthma

In order to qualify for the 6 week run-in, patients must have poorly controlled asthma as
defined by the following criteria:

1. Diagnosis of asthma confirmed either by demonstrating a positive methacholine
challenge test (defined as a decrease in FEV1 by at least 20%, following
administration of 8mg or less of inhaled methacholine) or a positive bronchodilator
response (defined as a change from base line of >12% and at least 200ml in either
FEV1 or FVC, following administration of a short-acting, inhaled bronchodilator).

2. Either:

- Asthma Control Questionnaire score > 1.5 or

- Use of inhaled rescue ß-agonist >/= 16 puffs per week (excluding use as a
pre-medication for exercise; 1 nebulizer treatment = 2 puffs of inhaler) at any
time during the past month or

- >1 hospitalization or unscheduled MD visit in the past 6 months for asthma
symptoms or

- >1 course of oral steroid use in past 6 months or

- > 2 weeks of systemic steroids in last 6 months.

Exclusion Criteria:

1. Current smokers or those with at least a 10 pack-year smoking history

2. Presence of any concurrent diseases that, in the investigator's opinion, would
interfere with participation in the study or that might put the participant at risk