Vitamin D Supplementation Reduces Renin-Angiotensin System Activity in Obesity
| Status: | Archived |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), Obesity Weight Loss, Other Indications, Gastrointestinal |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Endocrinology, Gastroenterology, Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | February 2010 |
| End Date: | April 2011 |
Vitamin D Deficiency Augments Renin-Angiotensin System Activity in Obesity
Hypothesis: Vitamin D supplementation lower renin-angiotensin system activity in obesity.
Specific Aim: To investigate whether Vitamin D supplementation in obesity improves the
vascular sensitivity to angiotensin II.
Vitamin D deficiency and obesity are international epidemics that have both been associated
with increased activity of the renin-angiotensin system (RAS). Because increased RAS
activity is associated with cardiovascular disease, interventions to lower RAS will have
favorable public health impacts.
This study aims to evaluate whether the supplementation of Vitamin D in obese subjects will
lower local tissue RAS activity. RAS activity will be evaluated by cross-sectional
measurement of RAS components and by quantifying the vascular response to an infusion of
angiotensin II. Subjects will be studied while Vitamin D deficient, and will return for
repeat study following Vitamin D supplementation, for comparison.
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