Thiamine as a Metabolic Resuscitator in Septic Shock
| Status: | Completed |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | February 2010 |
| End Date: | November 2014 |
The major goal of this project is to determine whether the use of thiamine in patients with
septic shock will result in attenuation of lactic acidosis and a more rapid reversal of
shock.
septic shock will result in attenuation of lactic acidosis and a more rapid reversal of
shock.
Inclusion Criteria:
- Greater than 18 years old
- Suspected or confirmed source of infection
- Hypotension (systolic pressure <90 mmHg) after a minimum 20-30 cc/kg fluid bolus
followed by vasopressor-dependence.
- Lactic Acidosis > 3 mmol/dl
Exclusion Criteria:
- Competing cause of lactic acidosis including: seizures within 3 hours of enrollment,
use of linazolid metformin or anti-retrovirals at the time of enrollment, carbon
monoxide or cyanide poisoning, highly suspected or known ischemic bowel, and known
mitochondrial disorders
- Liver dysfunction specifically defined as AST or ALT elevation greater than 240
- Current Thiamine supplements or usage
- Competing indication for thiamine administration
- Cardiac Arrest
- DNR/DNI or comfort care status (DNR status in an intubated patient receiving full
care is eligible)
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Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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