Peripheral Blood Stem Cell Transplantation Using the CliniMACS Device



Status:Active, not recruiting
Conditions:Cancer, Blood Cancer, Lymphoma, Hematology, Hematology
Therapuetic Areas:Hematology, Oncology
Healthy:No
Age Range:Any - 22
Updated:6/3/2018
Start Date:May 2008
End Date:May 2019

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Trial Summary
Trial Overview
Inclusion Criteria

CHP 834 Unrelated and Partially Matched Related Donor Peripheral Stem Cell Transplantation With The CliniMACS Device for T and B Cell Depletion

T cell depletion utilizing the CliniMACS device will allow more precise, specific and
controlled graft engineering of peripheral blood stem cells from unrelated and partially
matched related donors without an increase in relapse or graft rejection and grade III or IV
acute graft versus host disease (GVHD).


Inclusion Criteria:

- All races are eligible

- Malignant diseases: Leukemias and Lymphomas

- Non-malignant diseases: Severe Aplastic Anemia, immunodeficiencies

Exclusion Criteria:

- Lansky or Karnofsky > 70

- Echo > 27% shortening fraction

- renal function:serum creatinine < 1.5 x for normal age

- no active untreated infection

- DLCO > 50% of predicted value

- Hepatic: AST and ALT < 3x upper limit of normal; bilirubin < 2.0.
We found this trial at
1
site
Children's Hospital of Wisconsin
9000 W Wisconsin Ave #270
Milwaukee, Wisconsin 53226
(414) 266-2000
Principal Investigator: Julie A Talano, MD
Phone: 414-266-4858
Children's Hospital of Wisconsin Nothing matters more than our children. At Children's Hospital of Wisconsin,...
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