Efficacy of Statins In Prevention of CIN

Due to the conflict in the available data, there are no practice guidelines that are
established in order to prevent contrast-induced nephropathy (CIN). Our goal is to determine
if statin therapy plus intravenous normal saline, in patients with chronic renal
insufficiency undergoing angiography, is superior to placebo plus intravenous normal saline
therapy in the prevention of CIN.

1. Inclusion Criteria:

- Adults > 18 years of age

- undergoing coronary or peripheral angiography with or without intervention

- Cr > 1.3 mg/dL or GFR < 60 mL/min

2. Exclusion Criteria:

- end-stage renal disease on dialysis

- acute renal failure

- previous iodinated contrast media exposure within 7 days of study entry

- history of hypersensitivity to statins

- pregnancy or lactation

- emergent coronary angiography, ST elevation myocardial infarction (STEMI), or
cardiogenic shock

- prisoners

- patients already on maximum dose of statins

- patient receiving N-acetylcysteine or sodium bicarbonate