The Role of Intestinal Inflammation in Irritable Bowel Syndrome (IBS)



Status:Archived
Conditions:Irritable Bowel Syndrome (IBS), Gastrointestinal
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:January 2009
End Date:June 2011

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Trial Summary
Trial Overview
Inclusion Criteria

The Role of Intestinal Inflammation in the Pathophysiology of IBS


The research project addresses the following hypotheses (A) the normal balance of beneficial
and detrimental commensal intestinal bacteria is deranged in IBS, with selective alterations
in clinically defined patient subsets i.e., diarrhea predominant IBS (D-IBS) and
post-infectious IBS (PI-IBS); (B) these changes in intestinal microflora are associated with
sub-clinical mucosal inflammation and activation of the mucosal immune system; and (C)
activation of the mucosal immune system leads to alterations in gastrointestinal (GI)
functions (i.e., motility and sensation) and functional symptoms.


There are two main aims in the research study. The first aim is to determine whether
sub-clinical mucosal inflammation occurs in patients with D-IBS by identifying alterations
in mucosal markers for inflammation (inflammatory cytokines and inflammation-related
mediators). The second aim is to investigate whether the identifiable alterations in
inflammatory markers are associated with specific abnormalities in intestinal motor and
sensory functions that are relevant to the pathophysiology of IBS.


We found this trial at
1
site
University of North Carolina Hospital at Chapel Hill
101 Manning Dr
Chapel Hill, North Carolina 27599
(919) 966-4131
University of North Carolina Hospital at Chapel Hill The UNC Health Care System is a...
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mi
from
Chapel Hill, NC
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