Multimodal Neurodiagnostic Imaging of Traumatic Brain Injury and Post-Traumatic Stress Disorder
| Status: | Completed |
|---|---|
| Conditions: | Neurology, Psychiatric |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | August 2008 |
| End Date: | August 2014 |
Evidence Based Multimodal Neurodiagnostic Imaging of Traumatic Brain Injury and Post-Traumatic Stress Disorder at the Saint Louis University Advanced Neurosurgical Innovation Center (SANIC)
The purpose of this study is to determine whether the brains of persons with and without
traumatic brain injury differ in a meaningful way when advanced technology images of the
brain are taken using three newer technologies that visualize the brain using a combination
of external/internal magnetic fields and radioactive tracers (molecules that emit detectable
particles). The hope is that the results of this study will validate tools (help prove that
diagnostic tools actually detect disease) for the diagnosis and treatment of traumatic brain
injuries (TBI).
traumatic brain injury differ in a meaningful way when advanced technology images of the
brain are taken using three newer technologies that visualize the brain using a combination
of external/internal magnetic fields and radioactive tracers (molecules that emit detectable
particles). The hope is that the results of this study will validate tools (help prove that
diagnostic tools actually detect disease) for the diagnosis and treatment of traumatic brain
injuries (TBI).
'Normal' appearing brain is often not normal when imaged with advanced neuroimaging
techniques. It has been advocated that a battery of neurological assessments (including MEG)
be developed to assess mild traumatic brain injury (TBI) and studies have shown that
somatosensory evoked fields in severe TBI can serve as a measure of cortical function in
comatosed TBI patients. Functional neuroimaging techniques such as PET and fMRI may reveal
abnormalities in areas considered 'normal' on traditional MRI. Most significantly, advanced
functional neuroimaging may enable customized neurorehabilitation planning with more
efficient use of resources.
The study aim is to compare healthy brains, civilian TBI brains, and combat-related TBI to
identify correlations between abnormal imaging parameters with neurorehabilitation potential
utilizing advanced neurological imaging.
The study hypothesis states Severity of Traumatic Brain Injury (TBI) and Post-traumatic
Stress Disorders (PTSD) can be detected and quantified using a multimodal battery of
neurodiagnostic imaging techniques (MEG, PET/CT, 3 Tesla-MRI w/ DTI and fMRI) and
rehabilitation potential can be predicted in the post acute phase.
techniques. It has been advocated that a battery of neurological assessments (including MEG)
be developed to assess mild traumatic brain injury (TBI) and studies have shown that
somatosensory evoked fields in severe TBI can serve as a measure of cortical function in
comatosed TBI patients. Functional neuroimaging techniques such as PET and fMRI may reveal
abnormalities in areas considered 'normal' on traditional MRI. Most significantly, advanced
functional neuroimaging may enable customized neurorehabilitation planning with more
efficient use of resources.
The study aim is to compare healthy brains, civilian TBI brains, and combat-related TBI to
identify correlations between abnormal imaging parameters with neurorehabilitation potential
utilizing advanced neurological imaging.
The study hypothesis states Severity of Traumatic Brain Injury (TBI) and Post-traumatic
Stress Disorders (PTSD) can be detected and quantified using a multimodal battery of
neurodiagnostic imaging techniques (MEG, PET/CT, 3 Tesla-MRI w/ DTI and fMRI) and
rehabilitation potential can be predicted in the post acute phase.
Inclusion Criteria:
1. At least 18 years of age and non-active duty
2. Either:
1. Normal (no history of head injury) -OR-
2. TBI (injury since Jan. 1, 2002)
Exclusion Criteria:
1. Incapable of informed consent or absence of legally authorized representative.
2. Incarcerated (or subject to court supervision).
3. Known allergy to protocol contrast/imaging agent (or pregnant and unable to receive
agent)
4. MRI incompatible (i.e. implant, metal, > 300 lbs, severe claustrophobia)
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