Gastric Accommodation and Gastroesophageal Reflux
| Status: | Terminated |
|---|---|
| Conditions: | Gastroesophageal Reflux Disease , Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 1 - 30 |
| Updated: | 3/23/2019 |
| Start Date: | March 2010 |
| End Date: | November 2010 |
Gastric Accommodation as a Factor Influencing the Number of Reflux Episodes in Children and Adolescents
Gastroesophageal reflux events generally happen during relaxation of lower esophageal
sphincter. This relaxation is a reflex that is triggered by gastric stimuli. The
investigators hypothesize that abnormal relaxation of the gastric wall after a meal may lead
to reflux events. To test this hypothesis, a study was designed to measure the gastric
accommodation in patients undergoing esophageal impedance monitoring.
sphincter. This relaxation is a reflex that is triggered by gastric stimuli. The
investigators hypothesize that abnormal relaxation of the gastric wall after a meal may lead
to reflux events. To test this hypothesis, a study was designed to measure the gastric
accommodation in patients undergoing esophageal impedance monitoring.
Gastroesophageal reflux events happen during relaxations of lower esophageal sphincter not
related to swallowing, called transient. These transient lower esophageal sphincter
relaxations (tLESR) are generally triggered by gastric distension and its physiological
purpose is to vent the stomach. The gastric accommodation is a physiological process in which
the gastric fundus actively relaxes during a meal in order to accommodate it.
This study is driven by the hypothesis that impairment of the gastric accommodation may
facilitate triggering tLESR and, therefore, reflux events. We aim to evaluate the relation
between gastric fundic relaxation and the number of gastroesophageal reflux events in
children. We also aim to evaluate if there is a relation between the gastric emptying and the
number of reflux episodes.
related to swallowing, called transient. These transient lower esophageal sphincter
relaxations (tLESR) are generally triggered by gastric distension and its physiological
purpose is to vent the stomach. The gastric accommodation is a physiological process in which
the gastric fundus actively relaxes during a meal in order to accommodate it.
This study is driven by the hypothesis that impairment of the gastric accommodation may
facilitate triggering tLESR and, therefore, reflux events. We aim to evaluate the relation
between gastric fundic relaxation and the number of gastroesophageal reflux events in
children. We also aim to evaluate if there is a relation between the gastric emptying and the
number of reflux episodes.
Inclusion Criteria:
- children and adolescents older than 1-year old who were referred for combined
esophageal impedance pH monitoring for GERD* symptoms
Exclusion Criteria:
- continuous feeding
- previous fundoplication
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