The Saint Francis Remote Ischemic Preconditioning Trial (SaFR)
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 40 - 80 |
| Updated: | 4/2/2016 |
| Start Date: | March 2010 |
| End Date: | September 2011 |
| Contact: | Elizabeth Haag, RN CCRP |
| Email: | Elizabeth.Haag@chsli.org |
| Phone: | 5165626790 |
This study tests the hypothesis that repeated inflation of a blood pressure cuff on the arm
will improve results of coronary stent implantation by:
- reducing chest pain and electrocardiogram changes during balloon inflation to place the
stent
- reducing leakage of heart muscle protein(troponin) into the blood stream after stent
placement, indicated reduced damage to heart muscle during stent implantation
- increases in molecules in the blood that promote dilation of arteries
- reduced evidence of heart muscle damage on MRI immediately after stenting
- improved patient outcomes over six months with fewer adverse cardiovascular
events(heart attack, acute coronary syndrome,renarrowing of the stented artery, heart
failure, death, stroke, transient ischemic attack)
- improved heart structure and function at 6 months after stenting
will improve results of coronary stent implantation by:
- reducing chest pain and electrocardiogram changes during balloon inflation to place the
stent
- reducing leakage of heart muscle protein(troponin) into the blood stream after stent
placement, indicated reduced damage to heart muscle during stent implantation
- increases in molecules in the blood that promote dilation of arteries
- reduced evidence of heart muscle damage on MRI immediately after stenting
- improved patient outcomes over six months with fewer adverse cardiovascular
events(heart attack, acute coronary syndrome,renarrowing of the stented artery, heart
failure, death, stroke, transient ischemic attack)
- improved heart structure and function at 6 months after stenting
Inclusion Criteria:
- Patients with stable chronic coronary artery disease scheduled for elective
percutaneous intervention.
Exclusion Criteria:
- Recent (1 month) myocardial infarction
- Acute coronary syndrome
- Chest pain at res
- Estimated glomerular filtration rate(GFR)<45 mL/min/1.73 m2
- Frequent premature atrial or ventricular contractions or atrial fibrillation
- Any contraindication to MRI including implanted non MRI compatible medical devices or
ferromagnetic materials such as shrapnel
- Inability to breath-hold
- Severe claustrophobia
- Deafness
- Persistent tremor
- Inability to follow instructions.
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