Effects of Oxytocin on Behavior and Physiology in a Psychotherapy Setting



Status:Completed
Conditions:Anxiety
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:Any
Updated:10/21/2012
Start Date:December 2008
End Date:December 2010
Contact:Kai MacDonald, MD
Email:ksmacdonald@ucsd.edu
Phone:619-203-7393

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Physiologic Correlates of Perceived [Therapist] Empathy and Social-Emotional Process During Psychotherapy: Testing Oxytocin in a Cross-Over Design Pilot Study


Subjects—currently in outpatient mental health care--will participate in 2 psychotherapy
sessions, one with oxytocin spray and one with placebo spray. Sessions will be videotaped,
and cortisol and heart rate will be measured. We hypothesize that oxytocin will have
positive benefits on nonverbal behavior in the therapy session, as well as have positive
effects on subjective anxiety, cortisol and heart rate.


Inclusion Criteria:

- in current mental health treatment

- male 18-65

Exclusion Criteria:

- diagnosis of schizophrenia or psychosis

- diagnosis of autism or Aspergers disorder

- active substance use disorder

- at moderate or high risk of self-harm
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