Study To Assess Fracture Healing With Sclerostin Antibody

Inclusion Criteria:

- Males and females, age 55 to 95 years

- Fresh unilateral low energy intertrochanteric or femoral neck fracture as the primary
injury

- Intertrochanteric fractures eligible for this study must have at least two displaced
fragments

- Internal fixation of the intertrochanteric fracture with sliding hip screw or
intramedullary nail

- Internal fixation of femoral neck fracture with either a sliding hip screw or at
least three cancellous screws

Exclusion Criteria:

- Major polytrauma or significant axial trauma

- Presence of concomitant injuries such as rib fractures, wrist fractures, or acute
symptomatic vertebral fractures which severely impair the ability to rise from a
chair

- Inability to independently rise from armchair or walk 200 meters before hip fracture
(use of unilateral assistive device or rolling walker is acceptable)

- Severe symptomatic osteoarthritis of the lower extremity

- Cognitive deficit or symptomatic neurological conditions such as Parkinson's disease
or persistent gross motor or sensory deficits such as hemiparesis or hemiplegia

- Use of bone grafts at the time of fracture fixation

- Pathological fracture or metabolic or bone disease

- History of facial nerve paralysis or symptomatic spinal stenosis that has not been
surgically corrected. If surgically corrected, the subject must be asymptomatic to be
eligible for the study

- Malignancy within the last 5 years

- Evidence of the following (currently or within the past 5 years): elevated
transaminases, significantly impaired renal function, current hyper- or
hypocalcaemia, hypoalbuminemia

- Use of agents affecting bone metabolism