Prophylactic Continuous Positive Airway Pressure (CPAP) in Delivery Room, in the Prevention of Transient Tachypnea of Newborn (TTN): A Randomized Controlled Trial
| Status: | Completed |
|---|---|
| Conditions: | Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/21/2016 |
| Start Date: | November 2009 |
| End Date: | April 2013 |
Prophylactic CPAP/PEEP in Delivery Room (DR) Resuscitation, Effects on Natriuretic Peptide in the Prevention of Transient Tachypnea of Newborn (TTN): A Randomized Controlled Trial
Transient Tachypnea of the Newborn (TTN) is a disorder of delayed clearance of lung liquid
and a common cause of admission of full term infants and late pre term infants (34 to 36
weeks) to Neonatal Intensive Care Units (NICU). Both late preterm gestational age at
delivery, and mode of delivery are considered risk factors for TTN. The investigators
hypothesize that CPAP administered prophylactically in the Delivery Room via a T piece based
infant resuscitator Neopuff, to neonates at increased risk for TTN, would decrease the
incidence of TTN and thus decrease the need for hospitalization in the NICU. This is a pilot
study to evaluate the prophylactic administration of CPAP in the Delivery Room towards
prevention of TTN and it's effects on natriuretic peptides.The study will be conducted as a
randomized control trial after obtaining informed consents from the parents of eligible
infants. Infants will be randomized to receive either experimental treatment (prophylactic
CPAP) or standardized care.
and a common cause of admission of full term infants and late pre term infants (34 to 36
weeks) to Neonatal Intensive Care Units (NICU). Both late preterm gestational age at
delivery, and mode of delivery are considered risk factors for TTN. The investigators
hypothesize that CPAP administered prophylactically in the Delivery Room via a T piece based
infant resuscitator Neopuff, to neonates at increased risk for TTN, would decrease the
incidence of TTN and thus decrease the need for hospitalization in the NICU. This is a pilot
study to evaluate the prophylactic administration of CPAP in the Delivery Room towards
prevention of TTN and it's effects on natriuretic peptides.The study will be conducted as a
randomized control trial after obtaining informed consents from the parents of eligible
infants. Infants will be randomized to receive either experimental treatment (prophylactic
CPAP) or standardized care.
Inclusion Criteria:
- Babies born to mothers via elective CS: elective CS defined as planned CS in the
absence of Labor.
- Late preterm infants (34 1/7 to 36 6/7 weeks gestational age)
Exclusion Criteria:
- Presence of any of the risk factors for neonatal sepsis such as Prolonged Rupture of
Membranes for ≥18 hours (PROM), maternal fever, maternal chorioamnionitis or positive
maternal GBS colonization
- Need for use of PPV for perinatal depression or other indications
- Presence of any of the following
- congenital malformations (diagnosed prenatally)
- chromosomal anomalies (diagnosed prenatally)
- congenital heart disease diagnosed by fetal echocardiography.
We found this trial at
1
site
Click here to add this to my saved trials
