Induction Chemotherapy Followed By Cetuximab and Radiation in HPV-Associated Resectable Stage III/IV Oropharynx Cancer

OBJECTIVES:

Primary

- To evaluate the efficacy of induction therapy comprising paclitaxel, cisplatin, and
cetuximab followed by cetuximab in combination with low-dose or standard-dose
intensity-modulated radiotherapy, as measured by 2-year progression-free survival
(PFS), in patients with human papillomavirus(HPV)-associated resectable stage III-IVB
squamous cell carcinoma of the oropharynx.

Secondary

- To assess overall survival.

- To evaluate the objective response, local control, and metastatic rate.

- To evaluate early and late toxicities of treatment.

Tertiary

- To evaluate quality of life and speech and swallowing function as measured by
Functional Assessment of Cancer Therapy - General (FACT-G), Functional Assessment of
Cancer Therapy-Head and Neck (FACT-HN), and Vanderbilt Head and Neck Symptom Survey
(VHNSS).

- To assess the effect of treatment-induced fatigue on general physical functioning in
patients with head and neck cancer.

- To correlate functional decline with clinical, physical, and biologic correlatives.

- To evaluate radiation-resistance markers, including ERCC1 single nucleotide
polymorphism and protein expression, and to correlate them with treatment efficacy.

- To demonstrate the usefulness of biomarkers, including ERCC1, epidermal growth factor
receptor (EGFR), cytokine and chemokine markers, and plasma transforming growth factor
alpha (TGFA) and transforming growth factor beta (TGFB) levels, in predicting
progression-free survival (PFS) and other outcome parameters.

- To evaluate the correlation between the efficacy of cetuximab and polymorphisms in
FcγR-receptors.

- To evaluate functional outcome and biological parameters, including telomere length,
angiotensin-converting enzyme polymorphism, and C-reactive protein level.

OUTLINE: This is a multicenter study.

- Induction therapy: Patients receive cisplatin intravenously (IV) over 1 hour on day 1
and paclitaxel IV over 3 hours and cetuximab IV over 1-2 hours on days 1, 8, and 15.
Treatment repeats every 21 days for 3 courses. Patients then undergo evaluation of
response to induction therapy. Patients with a clinical complete response (CR) at the
primary tumor site proceed to group 1 of concurrent radiotherapy and cetuximab.
Patients with a clinical partial response (PR) or stable disease (SD) at the primary
tumor site or those with grossly positive disease at the primary tumor site proceed to
group 2 of concurrent radiotherapy and cetuximab.

- Concurrent radiotherapy and cetuximab: Treatment begins 14-21 days after the last day
of induction therapy.

- Group 1 (CR): Patients undergo low-dose intensity-modulated radiotherapy (IMRT) 5
days per week for approximately 5 weeks (27 fractions). Patients also receive
cetuximab IV over 1-2 hours once weekly for 6 weeks.

- Group 2 (PR, SD, or grossly positive disease): Patients undergo standard-dose IMRT
5 days per week for approximately 6 weeks (33 fractions). Patients also receive
cetuximab IV over 1-2 hours once weekly for 7 weeks.

Patients complete questionnaires assessing fatigue, physical function, weight loss, quality
of life, head and neck symptom burden, and speech and swallowing function at baseline and at
1, 6, 12, and 24 months after completion of study treatment.

Tumor tissue and serum samples may be collected periodically for correlative laboratory
studies.

After completion of study treatment, patients are followed up periodically for 3 years.

PROJECTED ACCRUAL: 83 patients

Inclusion Criteria:

- Histologically or cytologically confirmed squamous cell carcinoma of the oropharynx
as determined by Hematoxylin and eosin (H&E) staining

- Newly diagnosed disease

- Resectable disease OR disease that is expected to become resectable after study
treatment

- Stage III, IVA, or IVB disease as determined by imaging studies (computed
tomography (CT) scan with IV contrast or magnetic resonance imaging (MRI)
required) and a complete head and neck exam

- Paraffin-embedded tumor specimen available for central confirmation of HPV-associated
disease as determined by H&E staining and in-situ hybridization (ISH) for HPV-16 and
immunohistochemistry (IHC) for p16

- HPV-associated disease is defined as p16 IHC-positive and/or HPV-16 ISH-positive

- Non-HPV-associated disease is defined as p16 IHC-negative

- NOTE: If there is limited tumor material, p16 IHC will be performed before
HPV-16 ISH

- Measurable disease of the primary tumor or nodes by clinical and radiographic
methods, defined as a lesion that is ≥ 2 cm in at least one dimension by clinical
exam AND by radiographic exam with CT scan or MRI (or a lesion that is ≥ 1 cm in at
least one dimension if the radiographic exam utilizes spiral CT scan)

- No primary tumor or nodal metastasis fixed to the carotid artery, skull base, or
cervical spine

- No evidence of distant metastases

- Eastern Cooperative Oncology Group performance status 0-1

- Granulocytes ≥ 1,000/mm^3

- Platelet count ≥ 100,000/mm^3

- Total serum bilirubin ≤ 1.5 mg/dL

- Creatinine clearance ≥ 60 mL/min

- Negative pregnancy test

- Fertile patients must use effective contraception

- No history of another malignancy (except for carcinoma in situ of the cervix and/or
nonmelanomatous skin cancer) unless it has been curatively treated and the patient
has been disease-free for ≥ 2 years

- Patients with any of the following within the past 6 months are eligible provided
they have been evaluated by a cardiologist and/or neurologist before study entry:

- New York Heart Association (NYHA) class III-IV congestive heart failure

- Cerebrovascular accident or transient ischemic attack

- Unstable angina

- Myocardial infarction (with or without ST elevation)

Exclusion Criteria:

- Prior chemotherapy

- Prior radiotherapy above the clavicles

- Prior surgery with curative intent for this disease (complete head and neck exam with
biopsy allowed)

- Prior therapy specifically and directly targeting the EGFR pathway

- Prior severe infusion reaction to a monoclonal antibody

- Uncontrolled diabetes, uncontrolled infection despite antibiotics, or uncontrolled
hypertension within the past 30 days

- Concurrent illness likely to interfere with study therapy or to prevent surgical
resection

- Pregnant or nursing