Identifying and Treating Arousal Related Deficits in Neglect and Dysphagia

Neglect and dysphagia are two of the most problematic behavioral disorders encountered in
stroke rehabilitation with 300,000 patients affected annually in the US. Both disorders
impede progress in therapy and both lead to costly medical complications, like falls which
are associated with neglect and aspiration pneumonia and malnutrition which are associated
with dysphagia. No widely accepted pharmacological treatment exists for either disorder.

A new direction of this application is to view neglect and dysphagia as different disorders
that share a common deficit in magnitude estimation (ME). ME refers to one's ability to
perceive the intensity of sensory stimulation. Deficits in ME explain how much of a stimulus
is neglected by stroke patients. Sensory deficits are also known to produce dysphagia.
Perceptual deficits influence how patients response to stimuli like failing to act on all
stimuli present (neglect) and failing to generate swallowing reflexes sufficient for normal
bolus flow (dysphagia).

We know from previous work that ME is altered by change in cortical arousal following stroke
(decreased or hypoarousal). Hypoarousal is evidenced by objective and subjective post-stroke
fatigue and daytime sleepiness which occurs in 50% of stroke patients and can persist
chronically. Increasing arousal could potentially reverse the perceptual deficits associated
with hypoarousal and improve neglect and dysphagia. This proposal manipulates arousal in two
ways. Cold pressor stimulation, immersing the foot in cold water for 50 seconds, is used to
increase arousal and reverse neglect and dysphagia temporarily. A brief, 3-day trial of
modafinil (Provigil) versus placebo is then used in stroke patients to learn if a positive
response to cold-pressor stimulation can predicts patients who respond positively to
modafinil.

Inclusion Criteria:

- Signed informed consent

- Willingness to complete study procedures

- Ability to comprehend and sign informed consent

- Evidence of unilateral, ischemic stroke based on:

- Neuroimaging (clinically obtained imaging studies showing evidence of stroke)

- Acceptable categories of stroke include:

- Unilateral ischemic stroke

- Atherothrombotic stroke

- Cardioembolic stroke

- Lacunar stroke >1.5 cm

- Chronic stable, unilateral hemorrhagic stroke

- Or Behavioral evidence of stroke including:

- Hemiplegia

- Unilateral sensory impairment

- Localized higher cortical dysfunction (e.g. neglect,dysphagia, apraxia)

Exclusion Criteria:

- Cardiac valvular disease

- Left heart hypertrophy

- Poorly controlled hypertension

- Active variant angina

- Pre-menopausal women capable of having children, including those using active
contraception (precaution for study medication and not applicable to normal subjects)

- Severe renal or hepatic disease

- History of psychosis or substance abuse

- Patients on other CNS stimulants, dopamine agonists or antagonists (antipsychotics)

- Severe speech comprehension deficit and/or inability to communicate responses

- Allergies that could put the research subject at risk during the course of the study

- Cannot speak English

- Active cerebral neurologic disease other than stroke such as multiple sclerosis or
Alzheimer's Disease

- Active psychiatric illness except past history of treated depression or anxiety
disorders

- For persons needing an MRI - standard MRI exclusion criteria (cardiac pacemaker or
defibrillator, artificial heart valves, metallic aneurysm clips eye or ear implants,
implanted insulin or infusion pumps, battery activated stimulators, and history of
claustrophobia)

- Concomitant medications excluded: Based on recommendations of manufacturer, the
following concomitant medications are excluded: Tricyclic antidepressants and
Monoamine oxidase (MAO) inhibitors. Any other CNS stimulation producing medications.
Antifungal agents Itraconazole or Ketoconazole as plasma concentrations of modafinil
may be increased.

- Stroke patients will be excluded from the modafinil trial if they cannot swallow a
capsule.

- Stroke patients are excluded if they are able to become pregnant

- Any other criteria that the PI or study physicians feel would put the volunteer's
health at risk during the course of the study