Test-Retest Reliability of Pulmonary Function Tests in Patients With Duchenne's Muscular Dystrophy
| Status: | Completed |
|---|---|
| Conditions: | Neurology, Orthopedic |
| Therapuetic Areas: | Neurology, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 6 - 21 |
| Updated: | 2/7/2015 |
| Start Date: | March 2004 |
| End Date: | August 2005 |
| Contact: | Elena Morales, BS |
| Email: | elena.morales@choa.org |
Nearly all patients with Duchenne’s Muscular Dystrophy (DMD) have scoliosis. Posterior
instrumented spinal fusion, which is a surgery to correct scoliosis, has been shown to
improve quality of life and satisfaction of both parents and families. The progressive
muscular weakness leads to the development of scoliosis soon after the child has become
unable to walk. The muscular weakness and scoliosis also affect the pulmonary function of
these children. Pulmonary Function Tests (PFT) have been used to determine “pulmonary
fitness” prior to surgery as a way to determine how well or if the child will tolerate
surgery. Children with poor results on the PFT are determined to be too fragile to tolerate
such a large operation. The physicians conducting this study feel that the PFT may be
inaccurate and that this may not be the best single test to determine “pulmonary fitness”.
The physicians conducting the study think things like the time of day the study is done, how
tired you are when you complete the test, and how well you understand the test may affect
the results of the test.
instrumented spinal fusion, which is a surgery to correct scoliosis, has been shown to
improve quality of life and satisfaction of both parents and families. The progressive
muscular weakness leads to the development of scoliosis soon after the child has become
unable to walk. The muscular weakness and scoliosis also affect the pulmonary function of
these children. Pulmonary Function Tests (PFT) have been used to determine “pulmonary
fitness” prior to surgery as a way to determine how well or if the child will tolerate
surgery. Children with poor results on the PFT are determined to be too fragile to tolerate
such a large operation. The physicians conducting this study feel that the PFT may be
inaccurate and that this may not be the best single test to determine “pulmonary fitness”.
The physicians conducting the study think things like the time of day the study is done, how
tired you are when you complete the test, and how well you understand the test may affect
the results of the test.
All patients with DMD have routine PFT’s every six months as standard of care. You will be
randomized in to one of two groups. The group assignment will be chosen by chance, similar
to flipping a coin. If you are assigned to group one you will first have your regularly
scheduled PFT in the morning. You will be asked to complete a second PFT that afternoon as
least 4 hours after the first PFT. You will then be asked to come back to the clinic in two
weeks and repeat these PFT’s, once in the morning and once in the afternoon at least 4 hours
apart. Each PFT will take approximately 10 to 15 minutes. If you are assigned to group
two, you will have your regularly scheduled PFT in the morning and then a second test in the
afternoon at least four hours after the first test. After the second PFT you will receive
training from a Respiratory Therapist. You will receive teaching handouts to take home and
an incentive spirometer and peak flow meter to practice with. You will be asked to practice
these tests 2 times a day and record your results. You will then be asked to come back to
the clinic in two weeks to repeat 2 PFT’s, once in the morning and again at least 4 hours
later. All participants will be asked how they feel at the time of testing.
randomized in to one of two groups. The group assignment will be chosen by chance, similar
to flipping a coin. If you are assigned to group one you will first have your regularly
scheduled PFT in the morning. You will be asked to complete a second PFT that afternoon as
least 4 hours after the first PFT. You will then be asked to come back to the clinic in two
weeks and repeat these PFT’s, once in the morning and once in the afternoon at least 4 hours
apart. Each PFT will take approximately 10 to 15 minutes. If you are assigned to group
two, you will have your regularly scheduled PFT in the morning and then a second test in the
afternoon at least four hours after the first test. After the second PFT you will receive
training from a Respiratory Therapist. You will receive teaching handouts to take home and
an incentive spirometer and peak flow meter to practice with. You will be asked to practice
these tests 2 times a day and record your results. You will then be asked to come back to
the clinic in two weeks to repeat 2 PFT’s, once in the morning and again at least 4 hours
later. All participants will be asked how they feel at the time of testing.
Inclusion Criteria:
- Male
- Duchenne’s Muscular Dystrophy with diagnosed confirmed by a neurologist
- No longer able to ambulate for any meaningful amount of time
- No previous spinal operation
Exclusion Criteria:
- Any other type of muscular dystrophy or spinal muscular atrophy
- Tracheotomy
- Contractures of the upper extremities that would preclude using arm span as an
estimation for height
- Previous spinal surgery
- Asthma, recurrent pneumonia, or other chronic lung disease
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