Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF)
| Status: | Recruiting |
|---|---|
| Conditions: | Pneumonia, Pulmonary, Dermatology |
| Therapuetic Areas: | Dermatology / Plastic Surgery, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/17/2018 |
| Start Date: | July 2008 |
| End Date: | June 2019 |
| Contact: | Julie Powers, MHS |
| Email: | julia.powers@ucdenver.edu |
| Phone: | 303-724-6539 |
The purpose of this study is to investigate inherited genetic factors that play a role in the
development of familial pulmonary fibrosis and to identify a group of genes that predispose
individuals to develop pulmonary fibrosis. Finding the genes that cause pulmonary fibrosis is
the first step at developing better methods for early diagnosis and improved treatment for
pulmonary fibrosis. The overall hypothesis is that inherited genetic factors predispose
individuals to develop pulmonary fibrosis.
development of familial pulmonary fibrosis and to identify a group of genes that predispose
individuals to develop pulmonary fibrosis. Finding the genes that cause pulmonary fibrosis is
the first step at developing better methods for early diagnosis and improved treatment for
pulmonary fibrosis. The overall hypothesis is that inherited genetic factors predispose
individuals to develop pulmonary fibrosis.
Familial Pulmonary Fibrosis (FPF) is a sub-category of the idiopathic interstitial pneumonias
(IIPs). IIPs are progressive lung conditions, with limited treatment options and unknown
etiology. Though the IIPs have been associated with both genetic risk factors and
environmental exposures, the molecular mechanism underlying disease progression remain poorly
understood. This investigation seeks to identify a group of genetic loci that play a role in
the development of familial interstitial pneumonia (FIP) or FPF, where 2 or more cases of IIP
are seen within a family.
(IIPs). IIPs are progressive lung conditions, with limited treatment options and unknown
etiology. Though the IIPs have been associated with both genetic risk factors and
environmental exposures, the molecular mechanism underlying disease progression remain poorly
understood. This investigation seeks to identify a group of genetic loci that play a role in
the development of familial interstitial pneumonia (FIP) or FPF, where 2 or more cases of IIP
are seen within a family.
Inclusion Criteria:
- Two or more family members with a clinical diagnosis of Idiopathic Pulmonary Fibrosis
(IPF) or Idiopathic Interstitial Pneumonia (IIP)
- Additional family members may be eligible to participate if two family members are
suspected of or diagnosed as having Idiopathic Pulmonary Fibrosis (IPF) or Idiopathic
Interstitial Pneumonia (IIP)
Exclusion Criteria:
- Individuals whose pulmonary fibrosis is due to a known cause rather than idiopathic
- Individuals whose pulmonary fibrosis is due to a broader genetic syndrome
We found this trial at
4
sites
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13001 E. 17th Pl
Aurora, Colorado 80045
Aurora, Colorado 80045
303-724-5000
Principal Investigator: David A. Schwartz, MD
Phone: 303-724-6539
University of Colorado Denver The University of Colorado Denver | Anschutz Medical Campus provides a...
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Denver, Colorado 80206
Principal Investigator: David A. Schwartz, MD
Phone: 800-423-8891
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2201 West End Ave
Nashville, Tennessee 37232
Nashville, Tennessee 37232
(615) 322-7311
Principal Investigator: James E. Loyd, MD
Phone: 888-898-1550
Vanderbilt University Vanderbilt offers undergraduate programs in the liberal arts and sciences, engineering, music, education...
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