Study of Effects of L-Arginine in Colitis and Colon Cancer
| Status: | Completed |
|---|---|
| Conditions: | Colorectal Cancer, Cancer, Colitis, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/1/2017 |
| Start Date: | September 2009 |
| End Date: | December 2011 |
Immunomodulary Effects of Arginine Supplementation in Colitis and Colon Cancer
The purpose of this study is to look at the importance of L-Arginine in the digestive tract.
L-Arginine is an amino acid and is important in making proteins within the cell.
The evaluation of colon tissue, blood, urine, diet, health history, and symptoms will help
us learn more about L-Arginine and ulcerative colitis. The investigators believe these
studies will provide new insights into the treatment for Inflammatory Bowel Disease
(ulcerative colitis) and nutritional needs. The investigators plan to enroll 200
participants in this study over the next two years.
L-Arginine is an amino acid and is important in making proteins within the cell.
The evaluation of colon tissue, blood, urine, diet, health history, and symptoms will help
us learn more about L-Arginine and ulcerative colitis. The investigators believe these
studies will provide new insights into the treatment for Inflammatory Bowel Disease
(ulcerative colitis) and nutritional needs. The investigators plan to enroll 200
participants in this study over the next two years.
Amino acids are being measured in colon tissues and in serum by high performance liquid
chromotography (HPLC). Cytokines and chemokines are being measured in colon tissues and in
serum by Luminex assay. Cytokines and chemokines are also being measured in colon tissues by
real-time polymerase chain reaction (PCR) analysis of mRNA expression.
chromotography (HPLC). Cytokines and chemokines are being measured in colon tissues and in
serum by Luminex assay. Cytokines and chemokines are also being measured in colon tissues by
real-time polymerase chain reaction (PCR) analysis of mRNA expression.
Inclusion Criteria:
- 18 years of age or older
- Colonoscopy for one of the following: clinical indications, disease assessment, or
surveillance for dysplasia (as in ulcerative colitis)
- Screening for cancer
Exclusion Criteria:
- refusal to participate
- age less than 18 years at time of colonoscopy
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