Determining Levels of [D10] Phenanthrene Tetraol in Smokers' Urine
| Status: | Completed |
|---|---|
| Conditions: | Smoking Cessation |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 11/8/2014 |
| Start Date: | September 2007 |
| End Date: | December 2014 |
| Contact: | Stephen S Hecht, Ph.D. |
| Email: | hecht002@umn.edu |
| Phone: | 612-624-7604 |
The purpose of this research study is to better understand how people respond to
cancer-causing chemicals in cigarette smoke. Some people are able to get rid of these
chemicals as harmless agents while others suffer damage to their cells that can ultimately
result in cancer. We hope to develop a better understanding of how we can identify the
people who are in danger of getting cancer. Participants will complete questionnaires
regarding their health and smoking history. We will take blood samples to look at genes
which determine how the body breaks down some tobacco-related toxins. Participants will be
given a small amount of liquid to drink, containing alcohol, water, and a compound called
deuterated phenanthrene (DP), which is found in cigarette smoke and in the environment.
Phenanthrene is non-toxic and does not cause cancer, but this compound is broken down by the
body in the same way as cancer-causing agents. We will follow the pathway of this compound
as it is broken down in the body.
cancer-causing chemicals in cigarette smoke. Some people are able to get rid of these
chemicals as harmless agents while others suffer damage to their cells that can ultimately
result in cancer. We hope to develop a better understanding of how we can identify the
people who are in danger of getting cancer. Participants will complete questionnaires
regarding their health and smoking history. We will take blood samples to look at genes
which determine how the body breaks down some tobacco-related toxins. Participants will be
given a small amount of liquid to drink, containing alcohol, water, and a compound called
deuterated phenanthrene (DP), which is found in cigarette smoke and in the environment.
Phenanthrene is non-toxic and does not cause cancer, but this compound is broken down by the
body in the same way as cancer-causing agents. We will follow the pathway of this compound
as it is broken down in the body.
Forty apparently healthy smokers and non smokers (20 male, 20 female) will be recruited by
advertising in the Twin Cities area. This will be done by the Tobacco Use Research Center.
They will be screened in a phone call, then invited to come in for an orientation session
at which consent will be obtained. Pregnant smokers will be excluded. They will visit the
clinic weekly for 2 months and once monthly for 4 months for a total of 6 months
participation.
At each visit they will drink 5 ml of 50:50 ethanol:water containing 10 ug
[D10]phenanthrene. They will then collect their 24h urine and return it to the clinic. The
urine will be analyzed for [D10]phenanthrene tetraol. The goal of the study is to determine
the longitudinal stability of the amount of [D10]phenanthrene-tetraol in urine.
advertising in the Twin Cities area. This will be done by the Tobacco Use Research Center.
They will be screened in a phone call, then invited to come in for an orientation session
at which consent will be obtained. Pregnant smokers will be excluded. They will visit the
clinic weekly for 2 months and once monthly for 4 months for a total of 6 months
participation.
At each visit they will drink 5 ml of 50:50 ethanol:water containing 10 ug
[D10]phenanthrene. They will then collect their 24h urine and return it to the clinic. The
urine will be analyzed for [D10]phenanthrene tetraol. The goal of the study is to determine
the longitudinal stability of the amount of [D10]phenanthrene-tetraol in urine.
Inclusion Criteria:
- smokers and non-smokers
- smoking at least 10 cigarettes daily for the past year (for smokers)
- in good physical health (no unstable medical condition)
- stable, good mental health (not currently, within past 6 months, experiencing
unstable or untreated psychiatric diagnosis, including substance abuse, as determined
by the DSM-IV criteria).
Exclusion Criteria:
- subjects who have, within the past 6 months, experienced unstable or untreated
psychiatric diagnoses, including substance abuse, as determined by the DSM-IV
criteria.
- subjects using any other tobacco or nicotine products.
- female subjects who are pregnant or nursing.
- subjects with an unstable medical condition.
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