The Effects of Co-administration of Colesevelam and Sitagliptin on Glucose Metabolism in Subjects With Type 2 Diabetes Mellitus
| Status: | Archived |
|---|---|
| Conditions: | Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | March 2010 |
| End Date: | March 2012 |
This study will assess the effects of colesevelam, alone or in combination with sitagliptin,
on glucose metabolism in subjects with T2DM inadequately controlled by diet and exercise
The hypothesis is that co-administrationof colesevelam plus sitagliptin results in a greater
reduction in HbA1c compared to colesevelam HCl treatment by
1. improving the effects of colesevelam on fasting glucose metabolism
2. improving the effects of colsevelam on postprandial glucose metabolism
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