Sorafenib Tosylate and Erlotinib Hydrochloride in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gallbladder Cancer or Cholangiocarcinoma
| Status: | Archived |
|---|---|
| Conditions: | Liver Cancer, Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | May 2010 |
Phase II Study of Sorafenib (NSC-724772) and Erlotinib (NSC-718781) in Patients With Advanced Gallbladder Carcinoma or Cholangiocarcinoma
RATIONALE: Sorafenib tosylate and erlotinib hydrochloride may stop the growth of tumor cells
by blocking some of the enzymes needed for cell growth or by blocking blood flow to the
tumor.
PURPOSE: This phase II trial is studying how well giving sorafenib tosylate together with
erlotinib hydrochloride works in treating patients with locally advanced, unresectable, or
metastatic gallbladder cancer or cholangiocarcinoma.
OBJECTIVES:
- To assess the progression-free survival of patients with unresectable or metastatic
gallbladder carcinoma or cholangiocarcinoma treated with the combination of sorafenib
tosylate and erlotinib hydrochloride.
- To assess the overall survival of patients treated with this regimen.
- To assess the objective response rate in patients treated with this regimen.
- To assess the frequency and severity of toxicities of this regimen in these patients.
- To collect specimens for banking for future research.
OUTLINE: This is a multicenter study.
Patients receive oral sorafenib tosylate twice daily and oral erlotinib hydrochloride once
daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or
unacceptable toxicity.
After completion of study therapy, patients are followed up every 6 months for 3 years.
We found this trial at
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Via Christi Regional Medical Center Via Christi Health's rich history of serving the people of...
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Cancer Research Center of Hawaii The University of Hawaii Cancer Center is the only National...
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1415 E. Kincaid
Mount Vernon, Washington 98273
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M. D. Anderson Cancer Center Welcome to UF Health Cancer Center at Orlando Health. For...
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Harrison Poulsbo Hematology and Onocology Harrison Poulsbo's new Hematology & Oncology center provides outpatient cancer...
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2279 45th Street
Sacramento, California 95817
Sacramento, California 95817
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Seattle, Washington 98195
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Ann Arbor, Michigan 48106
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Billings Clinic - Downtown Based in Billings, Montana, Billings Clinic is a community-governed health care...
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1101 N 27th St # 201
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Cancer Center of Kansas, PA - Chanute Dr. H.E. Hynes founded Cancer Center of Kansas,...
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Charleston, South Carolina 29425
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Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Adena Regional Medical Center Since 1895, Adena Health System has remained focused on its commitment...
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Doctors Hospital Nationally recognized for care quality and patient safety and satisfaction, Doctors Hospital is...
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Mount Carmel Health - West Hospital Located near downtown Columbus, Mount Carmel West is the...
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Danville Regional Medical Center For more than 120 years, Danville Regional Medical Center has been...
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Dayton CCOP We are a regional non-profit cancer research consortium serving the Miami Valley area...
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Good Samaritan Hospital - Dayton Good Samaritan Hospital (GSH) is passionate about providing the most...
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Samaritan North Cancer Care Center At Good Samaritan Hospital (GSH), our licensed, board-certified staff uses...
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18101 Oakwood Blvd
Dearborn, Michigan 48124
Dearborn, Michigan 48124
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Oakwood Cancer Center at Oakwood Hospital and Medical Center In today's health care environment, a...
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2300 N. Edward Street
Decatur, Illinois 62526
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Decatur Memorial Hospital Cancer Care Institute An American flag bearing only 48 stars waved above...
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Grady Memorial Hospital As the center of healthcare in Delaware County, Grady Memorial Hospital is...
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Cancer Center of Kansas, PA - Dodge City Dr. H.E. Hynes founded Cancer Center of...
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Blanchard Valley Medical Associates Blanchard Valley Medical Associates was founded in 1974 by Dr. William...
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Cancer Center of Kansas - Fort Scott Dr. H.E. Hynes founded Cancer Center of Kansas,...
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1101 26th Street South
Great Falls, Montana 59405
Great Falls, Montana 59405
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Sletten Cancer Institute at Benefis Healthcare Benefis Hospitals has 516 beds at its two campuses...
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Wayne Hospital Stretching back to our roots nearly 100 years ago, Wayne HealthCare has always...
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114 Woodland St, Hartford
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Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center While better...
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Hays Medical Center Hays Medical Center is a private, not-for-profit hospital formed by the 1991...
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St. Peter's Hospital Welcome to St. Peter’s Hospital, providing premier health care to a five–county...
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Pardee Memorial Hospital Pardee Hospital is a not-for-profit community hospital founded in 1953 and is...
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1301 Punchbowl Street
Honolulu, Hawaii 96813
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Queen's Cancer Institute at Queen's Medical Center The Queen
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Oncare Hawaii Inc-Kuakini OnCare Hawaii is a Certified PROVENGE® Treatment Center. PROVENGE (sipuleucel-T) is the...
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Straub Clinic And Hospital Founded in 1921, Straub Clinic & Hospital is a fully integrated...
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Cancer Center of Kansas-Independence Dr. H.E. Hynes founded Cancer Center of Kansas, P. A. in...
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Foote Memorial Hospital Allegiance Health is a community-owned, locally-governed health system in Jackson, Michigan. We...
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Glacier Oncology, PLLC Glacier Oncology are physician clinics focusing exclusively on the medical subspecialties of...
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Kalispell Regional Medical Center Nestled in the beautiful Flathead Valley of Northwestern Montana, Kalispell Regional...
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Lawrence Memorial Hospital Lawrence Memorial Hospital (LMH), in collaboration with its medical staff, is dedicated...
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Cancer Center of Kansas, PA - Liberal Dr. H.E. Hynes founded Cancer Center of Kansas,...
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401 Matthew St
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Strecker Cancer Center at Marietta Memorial Hospital The Memorial Health System's Strecker Cancer Center combines...
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Knox Community Hospital A community-owned, 115-bed, not-for-profit hospital located in Mount Vernon, Ohio (approximately 40...
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