Sorafenib Tosylate and Erlotinib Hydrochloride in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gallbladder Cancer or Cholangiocarcinoma
| Status: | Archived |
|---|---|
| Conditions: | Liver Cancer, Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | May 2010 |
Phase II Study of Sorafenib (NSC-724772) and Erlotinib (NSC-718781) in Patients With Advanced Gallbladder Carcinoma or Cholangiocarcinoma
RATIONALE: Sorafenib tosylate and erlotinib hydrochloride may stop the growth of tumor cells
by blocking some of the enzymes needed for cell growth or by blocking blood flow to the
tumor.
PURPOSE: This phase II trial is studying how well giving sorafenib tosylate together with
erlotinib hydrochloride works in treating patients with locally advanced, unresectable, or
metastatic gallbladder cancer or cholangiocarcinoma.
OBJECTIVES:
- To assess the progression-free survival of patients with unresectable or metastatic
gallbladder carcinoma or cholangiocarcinoma treated with the combination of sorafenib
tosylate and erlotinib hydrochloride.
- To assess the overall survival of patients treated with this regimen.
- To assess the objective response rate in patients treated with this regimen.
- To assess the frequency and severity of toxicities of this regimen in these patients.
- To collect specimens for banking for future research.
OUTLINE: This is a multicenter study.
Patients receive oral sorafenib tosylate twice daily and oral erlotinib hydrochloride once
daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or
unacceptable toxicity.
After completion of study therapy, patients are followed up every 6 months for 3 years.
We found this trial at
150
sites
Cancer Center of Kansas The physicians of Cancer Center are hematologists and oncologists. The staff...
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Boston Med Center Boston Medical Center (BMC) is a 496-bed academic medical center located in...
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Olympic Hematology and Oncology We provide outpatient cancer services in a refined environment designed specifically...
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Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
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University of Florida Gainesville UF has a long history of established programs in international education,...
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2700 Wayne Memorial Drive
Goldsboro, North Carolina 27534
Goldsboro, North Carolina 27534
(919) 736-1110
Wayne Memorial Hospital, Incorporated Wayne Memorial Hospital, an affiliate of Wayne Health Corporation, is home...
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Cancer Research Center of Hawaii The University of Hawaii Cancer Center is the only National...
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1415 E. Kincaid
Mount Vernon, Washington 98273
Mount Vernon, Washington 98273
360-424-4111
Skagit Valley Hospital Cancer Care Center We know that treatment takes its toll physically, emotionally...
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M. D. Anderson Cancer Center Welcome to UF Health Cancer Center at Orlando Health. For...
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19500 10th Ave NE # 100
Poulsbo, Washington 98370
Poulsbo, Washington 98370
(360) 598-7500
Harrison Poulsbo Hematology and Onocology Harrison Poulsbo's new Hematology & Oncology center provides outpatient cancer...
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2279 45th Street
Sacramento, California 95817
Sacramento, California 95817
(916) 734-5800
University of California Davis Cancer Center At UC Davis Comprehensive Cancer Center, specialized teams of...
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4700 Waters Avenue
Savannah, Georgia 31404
Savannah, Georgia 31404
912-350-8490
Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center The Curtis and...
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1100 Fairview Avenue North
Seattle, Washington 98109
Seattle, Washington 98109
(206) 667-5000
Fred Hutchinson Cancer Research Center At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of...
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1959 NE Pacific St
Seattle, Washington 98195
Seattle, Washington 98195
(206) 598-4100
University Cancer Center at University of Washington Medical Center The Division of Radiation Oncology's work...
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Group Health Central Hospital Group Health Cooperative is a member-governed, nonprofit health care system that...
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601 South Sherman Street
Spokane, Washington 99202
Spokane, Washington 99202
(509) 228-1000
Cancer Care Northwest - Spokane South Cancer Care Northwest is the Inland Northwest’s premier cancer...
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Wenatchee Valley Medical Center Established on July 21, 2013, Confluence Health is an affiliation between...
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Kapiolani Medical Center at Pali Momi Pali Momi Medical Center is a nonprofit hospital located...
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5301 East Huron River Drive
Ann Arbor, Michigan 48106
Ann Arbor, Michigan 48106
1.877.590.5995
CCOP - Michigan Cancer Research Consortium The Community Clinical Oncology Program (CCOP) is a comprehensive...
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Mary Rutan Hospital The hospital was endowed by the sale of a farm in Ridgeway...
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St Luke'S Hospital And Health Network St. Luke's University Health Network (SLUHN) is a nonprofit,...
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Montana Cancer Consortium CCOP The Montana Cancer Consortium is a nonprofit organization whose mission is...
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Billings Clinic - Downtown Based in Billings, Montana, Billings Clinic is a community-governed health care...
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1101 N 27th St # 201
Billings, Montana 59101
Billings, Montana 59101
(406) 237-3585
St. Vincent Healthcare Cancer Care Services The Sisters of Charity of Leavenworth, Kansas, founded St....
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Bozeman Deaconess Cancer Center Bozeman Deaconess Cancer Center provides the latest cancer technologies and treatment...
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Rocky Mountain Oncology Rocky Mountain Oncology Center is a spacious, comfortable, state-of-the-art 19,000 square foot...
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Cancer Center of Kansas, PA - Chanute Dr. H.E. Hynes founded Cancer Center of Kansas,...
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171 Ashley Avenue
Charleston, South Carolina 29425
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Adena Regional Medical Center Since 1895, Adena Health System has remained focused on its commitment...
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Doctors Hospital Nationally recognized for care quality and patient safety and satisfaction, Doctors Hospital is...
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Mount Carmel Health - West Hospital Located near downtown Columbus, Mount Carmel West is the...
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Danville Regional Medical Center For more than 120 years, Danville Regional Medical Center has been...
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Dayton CCOP We are a regional non-profit cancer research consortium serving the Miami Valley area...
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Good Samaritan Hospital - Dayton Good Samaritan Hospital (GSH) is passionate about providing the most...
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Samaritan North Cancer Care Center At Good Samaritan Hospital (GSH), our licensed, board-certified staff uses...
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Grandview Hospital You'll feel like part of our family when you visit Grandview Medical Center...
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18101 Oakwood Blvd
Dearborn, Michigan 48124
Dearborn, Michigan 48124
(313) 593-8620
Oakwood Cancer Center at Oakwood Hospital and Medical Center In today's health care environment, a...
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2300 N. Edward Street
Decatur, Illinois 62526
Decatur, Illinois 62526
217-876-8121
Decatur Memorial Hospital Cancer Care Institute An American flag bearing only 48 stars waved above...
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Grady Memorial Hospital As the center of healthcare in Delaware County, Grady Memorial Hospital is...
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Cancer Center of Kansas, PA - Dodge City Dr. H.E. Hynes founded Cancer Center of...
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Cancer Center of Kansas, PA - El Dorado Dr. H.E. Hynes founded Cancer Center of...
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Blanchard Valley Medical Associates Blanchard Valley Medical Associates was founded in 1974 by Dr. William...
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Cancer Center of Kansas - Fort Scott Dr. H.E. Hynes founded Cancer Center of Kansas,...
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1101 26th Street South
Great Falls, Montana 59405
Great Falls, Montana 59405
406.455.5000
Sletten Cancer Institute at Benefis Healthcare Benefis Hospitals has 516 beds at its two campuses...
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Wayne Hospital Stretching back to our roots nearly 100 years ago, Wayne HealthCare has always...
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114 Woodland St, Hartford
Hartford, Connecticut 06105
Hartford, Connecticut 06105
(860) 714-4000
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center While better...
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Hays Medical Center Hays Medical Center is a private, not-for-profit hospital formed by the 1991...
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St. Peter's Hospital Welcome to St. Peter’s Hospital, providing premier health care to a five–county...
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Pardee Memorial Hospital Pardee Hospital is a not-for-profit community hospital founded in 1953 and is...
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1301 Punchbowl Street
Honolulu, Hawaii 96813
Honolulu, Hawaii 96813
(808) 538-9011
Queen's Cancer Institute at Queen's Medical Center The Queen
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Oncare Hawaii Inc-Kuakini OnCare Hawaii is a Certified PROVENGE® Treatment Center. PROVENGE (sipuleucel-T) is the...
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Straub Clinic And Hospital Founded in 1921, Straub Clinic & Hospital is a fully integrated...
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Cancer Center of Kansas-Independence Dr. H.E. Hynes founded Cancer Center of Kansas, P. A. in...
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Foote Memorial Hospital Allegiance Health is a community-owned, locally-governed health system in Jackson, Michigan. We...
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Glacier Oncology, PLLC Glacier Oncology are physician clinics focusing exclusively on the medical subspecialties of...
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Kalispell Regional Medical Center Nestled in the beautiful Flathead Valley of Northwestern Montana, Kalispell Regional...
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North Kansas City Hospital Generations of Northlanders have considered North Kansas City Hospital as their...
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Research Medical Center Research Medical Center offers hospital and health clinic services across three Kansas...
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Truman Medical Center Located in the heart of downtown Kansas City, TMC Hospital Hill is...
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Columbia Basin Hematology and Oncology Our collaboration with Seattle Cancer Care Alliance gives you convenient...
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Cancer Center of Kansas, PA - Kingman Dr. H.E. Hynes founded Cancer Center of Kansas,...
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Fairfield Medical Center We are people you know offering care you trust. Serving more than...
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Sparrow Regional Cancer Center Sparrow has grown to become the region's largest health system, and...
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Lawrence Memorial Hospital Lawrence Memorial Hospital (LMH), in collaboration with its medical staff, is dedicated...
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Saint Luke's East - Lee's Summit Founded in 2006, Saint Luke
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Cancer Center of Kansas, PA - Liberal Dr. H.E. Hynes founded Cancer Center of Kansas,...
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Liberty Hospital Liberty Hospital is a comprehensive medical center with a full range of services,...
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401 Matthew St
Marietta, Ohio 45750
Marietta, Ohio 45750
(740) 376-5000
Strecker Cancer Center at Marietta Memorial Hospital The Memorial Health System's Strecker Cancer Center combines...
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2160 S. First Ave.
Maywood, Illinois 60153
Maywood, Illinois 60153
888-584-7888
Cardinal Bernardin Cancer Center at Loyola University Medical Center The Cardinal Bernardin Cancer Center is...
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Montana Cancer Center at St. Patrick Hospital and Health Sciences Center St. Patrick Hospital is...
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500 W Broadway St
Missoula, Montana 59807
Missoula, Montana 59807
(406) 728-2539
Montana Cancer Specialists at Montana Cancer Center MCC is a comprehensive medical oncology, hematology and...
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Knox Community Hospital A community-owned, 115-bed, not-for-profit hospital located in Mount Vernon, Ohio (approximately 40...
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