Chronotherapy Versus Conventional BP Control to Correct Abnormal Circadian BP Pattern in Kidney Transplant Recipients
| Status: | Recruiting |
|---|---|
| Conditions: | Nephrology |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 10/21/2012 |
| Start Date: | December 2008 |
| Contact: | Hani Wadei, M.D. |
| Email: | wadei.hani@mayo.edu |
| Phone: | 904-956-3200 |
Randomized Trial to Explore the Effect of Chronotherapy Versus Conventional BP Control to Correct Abnormal Circadian BP Pattern and Improve Allograft Function in Kidney Transplant Recipients
The purpose of this study is to identify and manage factors related to blood pressure
control that impact organ function and survival in kidney transplant recipients. Loss of the
circadian (relating to a 24-hour rhythm) blood pressure pattern is common in kidney
transplant recipients and is associated with poor allograft kidney function. It is still
unclear if restoring the normal day-night blood pressure (BP) pattern will translate into
better allograft outcome. Although studies in patients with and without chronic kidney
disease indicate that restoration of the normal nocturnal (night) dipping in BP is possible
by changing the timing of the BP medications to cover the overnight period (chronotherapy),
this has not been tested in kidney transplant patients.
The challenge in kidney transplantation is to identify and manage factors that impact
allograft function and survival. Loss of the circadian blood pressure pattern is common in
kidney transplant recipients and is associated with poor allograft kidney function.
Nevertheless, it is unclear if restoring the normal day-night BP pattern will translate into
better allograft outcome. Although studies in patients with and without chronic kidney
disease indicate that restoration of the normal nocturnal dipping in BP is possible by
changing the timing of the BP medications to cover the overnight period (chronotherapy),
this has not been tested in kidney transplant patients. This exploratory study is driven by
the hypothesis that chronotherapy will restore the normal circadian BP pattern and will
translate into better allograft function and into lower LVM 1-year from transplantation.
Inclusion Criteria:
- Recipient of a kidney transplant.
- Age≥18 years.
- Stable allograft function.
- Ability to give informed consent.
Exclusion Criteria:
- Multiorgan transplant recipients.
- Kidney transplant recipients with poor allograft function.
- Documented history of obstructive sleep apnea.
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