Aliskiren in Patients With Idiopathic Membranous Nephropathy
| Status: | Archived |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease, Nephrology |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | November 2010 |
| End Date: | March 2012 |
A Pilot Study to Evaluate the Antiproteinuric Effect of Renin Inhibition With Aliskiren in Patients With Idiopathic Membranous Nephropathy
The goal of this proposal is to conduct a pilot study to access the antiproteinuric effect
of aliskiren in patients with idiopathic membranous nephropathy. Patients will be treated
for 3 months with aliskiren aiming to achieve the maximum tolerated dose and blood pressure
(>100 but <125 mmHg systolic BP >75% of the readings).
In patients with nephrotic syndrome, including patients with membranous nephropathy (MN),
conservative therapy consists of restricting dietary protein intake, and controlling blood
pressure (target blood pressure is ≤ 125/75 mmHg), hyperlipidemia, and edema.
Angiotensin-converting enzyme inhibitors (ACEi) and/or angiotensin II receptor blockers
(ARB) are effective anti-hypertensive agents that can reduce proteinuria and slow
progression of renal disease in both diabetic and nondiabetic chronic nephropathy patients
and for these reasons they are the preferred agents to treat hypertension in proteinuric
renal diseases.
Recent studies suggest that renin inhibition with aliskiren may be renoprotective and reduce
proteinuria in patients with type 2 diabetes. Similar observations have also been reported
in patients with membranous nephropathy and proteinuria in the range of 1-3 g/24h. These
observations suggest that aliskiren may have powerful antiproteinuric. However, it is
important to emphasize, that none of the patients in these studies had proteinuria greater
than 3.0 g/24h. Thus, the antiproteinuric effect of aliskiren in patients with heavy
proteinuria (e.g. >4g/24h) is unknown.
We found this trial at
1
site
Mayo Clinic College of Medicine Mayo Medical School enrolls a select class of 50 medical...
Click here to add this to my saved trials
