Phase 1 Study of Potential Anti-Inflammatory Effects of Glucose Control During Acute Myocardial Infarction.

Two out of three heart attack patients have high blood sugar. Half of these patients have
diabetes and the other half have what is called pre-diabetes, meaning that they have higher
blood sugar than normal but not high enough to have diabetes. Over 40 million Americans
have pre-diabetes.

For more than 70 years, doctors have known that patients with high blood sugar do not
survive or recover from heart attacks as well as patients with normal blood sugar. Doctors
have not figured out the reason for this difference.

The best treatment available for heart attacks is called angioplasty. Angioplasty means
that doctors put a small balloon into a blocked blood vessel, blow up the balloon to open
the blockage, and then insert a small wire tube called a stent to hold the blockage open.
Blood thinners and other heart medicines are also given to these patients to help blood get
through the blocked blood vessel. Angioplasty and these medicines have helped many people
survive and recover from heart attacks. But even when doctors use these drugs, balloons and
stents, patients who have high blood sugar still do worse than patients with normal blood
sugar.

We want to figure out why high blood sugar is bad for patients with heart attacks. Past
research tells us there might be two reasons. The first is that high blood sugar increases
inflammation which is part of the body’s natural response to heart attack. Inflammation is
what causes a person’s skin to turn hot and red after it is injured. Although inflammation
is part of the body’s natural healing process, too much inflammation can be harmful. We
think that patients with high blood sugar during heart attacks have too much inflammation.
The second reason why high blood sugar might be bad for heart attack patients is that high
blood sugar makes blood thicker. When a blood vessel is blocked, thick blood makes it
harder for the heart to get the blood flow it needs. This is why doctors use aspirin and
other blood thinners when they treat patients with heart attacks.

The amount of inflammation and thickness in a person’s blood can be measured in a
laboratory. In this study, we want to measure the amount of inflammation and thickness in
patients’ blood to see if there is a difference between patients with normal blood sugar,
patients with pre-diabetes, and patients with diabetes. If we can show that there is a
difference, this will help us to understand why high blood sugar is bad for patients with
heart attacks.

We also want to see if lowering a patient’s high blood sugar is helpful during a heart
attack. The standard therapy for lowering blood sugar in diabetic patients with heart
attacks is to check their blood sugar four times each day while they are in the hospital,
and to give them a shot of a medicine called insulin that helps bring the blood sugar level
down if it is high. However, research tells us that this way of treating diabetic patients
doesn’t get their blood sugar low enough. Also, patients with pre-diabetes and patients who
have diabetes but don’t know it usually don’t get any insulin, so their sugar levels are
usually allowed to run high while they are in the hospital. In this study, we will treat
half of diabetic and pre-diabetic patients the usual way and give the other half insulin
through an IV for the first 24 hours that they are in the hospital. If we compare the
inflammation and blood thickness between patients treated the usual way and patients treated
with more insulin, we can figure out if lowering blood sugar more than usual is helpful to
patients with heart attack.

If we can find out why high blood sugar is harmful to patients with heart attacks, and if we
can show that treating these patients with more insulin than usual lessens these harmful
effects, then we will be able to improve the way that these patients are treated. This
could result in better survival and recovery for many heart attack patients.

All patients who volunteer for this study will get the best treatment available for heart
attack- angioplasty, blood thinners, and the other heart medications that are usually given
to these patients. Patients who have high blood sugar will be divided into two groups. One
group will have their blood sugars measured and treated in the usual way. The other group
will be treated with insulin run through an IV for 24 hours. After 24 hours, all patients
will be treated in the usual way.

About one tablespoon of blood will be drawn from each patient at the time they sign up for
the study and then 6, 12, 24, and 48 hours later. This blood will be used to test for
inflammation and blood thickness.

The only ways in which patients who volunteer for this study will be treated differently
from the standard of care are that they might receive more insulin than usual and they will
have more blood drawn than usual. Giving extra insulin to these patients should not cause
them harm, and may even help them. Since only about 5 tablespoons of extra blood will be
drawn from each patient, this should not cause patients any harm.

Goals of this study

1. To see what happens to blood inflammation and thickness in heart attack patients with
normal blood sugar and compare this to patients with high blood sugar.

2. To find out lowering patients’ blood sugar levels more than we currently do will result
in less blood inflammation and thickness.

Inclusion Criteria: Patients to be treated with percutaneous coronary intervention for
myocardial infarction.

Exclusion Criteria: MI > 6 hrs duration Thrombolytic therapy (within last 2 days)
Recent inflammatory/infectious illness (last 2 weeks) Pregnancy Renal insufficiency (Cr >
2.0) Type I Diabetes Mellitus Initial BG >110 but <140 Enrollment in another research
study